Application of 3-aryl coumarin compound and insulin resistance preparation

A technology of insulin resistance and aryl coumarin, applied in the direction of active ingredients of heterocyclic compounds, drug combinations, metabolic diseases, etc., can solve problems such as gluconeogenesis dysfunction, hyperglycemia, oxidative stress, etc.

Pending Publication Date: 2021-11-23
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin resistance can lead to dysfunction of gluconeogenesis regulated by PI3K / AKT signaling pathway, leading to the occurrence of hyperglycemia
Sustained high blood sugar will cause the body to produce excessive ROS, leading to the occurrence of oxidative stress

Method used

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  • Application of 3-aryl coumarin compound and insulin resistance preparation
  • Application of 3-aryl coumarin compound and insulin resistance preparation
  • Application of 3-aryl coumarin compound and insulin resistance preparation

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Embodiment Construction

[0028] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0029] Unless otherwise specified, the content of each component used below is the content by weight percentage; the experimental methods used are all conventional methods; the reagents, biological materials, etc. used can be obtained from commercial sources.

[0030] The compound numbers and structural formulas involved in the embodiments of the present invention are as follows:

[0031]

[0032] 【Preparation Example】

[0033] The preparation process of compound I i.e. 3-(4'-hydroxyphenyl)-6-hydroxycoumarin is as follows:

[0034] In a 100mL three-necked reaction flask, add 1.52g (10mmol) 4-hydroxyphenylacetic acid, 1.38g (10mmol) 2,5-dihydroxybenzaldehyde, 5.56g (55mmol) triethylamine and 6.12g (60mmol) acetic anhydride , and then add magnetons, place in a microwave reactor, set the micro...

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Abstract

The invention relates to application of a 3-aryl coumarin compound and an insulin resistance preparation. The invention discloses application of a 3-aryl coumarin compound shown in a structural formula (I) in preparation of an insulin resistance preparation. Compared with the prior art, the 3-aryl coumarin compound has the advantages that the insulin resistance of diabetes patients is improved, and the secreted insulin can play a better role, so that the purposes of reducing blood sugar and treating diabetes are achieved, and the 3-aryl coumarin compound can be used for preparing an insulin resistance preparation and has very good popularization and application values..

Description

technical field [0001] The invention relates to the field of medicine production, and specifically provides an application of 3-arylcoumarin compounds and an insulin resistance preparation. Background technique [0002] Diabetes mellitus is a chronic, multifactorial metabolic disorder characterized by hyperglycemia, insulin resistance, and pancreatic β-cell dysfunction. Diabetic patients are extremely prone to cardiovascular disease, and cardiovascular complications are the leading cause of death in diabetic patients. Diabetes is currently the third non-communicable disease that threatens human health after cardiovascular and cerebrovascular diseases and malignant tumors. It has brought a heavy burden to society and the economy and seriously threatened human health. Diabetes itself is not terrible, what is terrible are its complications. Diabetic complications involve all organs of the body and are the main cause of serious diseases such as blood and cerebrovascular diseas...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P5/50A61P3/10
CPCA61K31/37A61P5/50A61P3/10
Inventor 孙捷孙小雅王晓静员银苓苗宇航张蔷潘银波郝灿华
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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