Application of arsenic trioxide and water-soluble substances thereof in preparation of medicine for treating atopic dermatitis

A technology for arsenic trioxide and atopic dermatitis, which is applied in the field of medicine to achieve the effects of reduced cytokine secretion, important clinical significance and market prospect, effective therapeutic effect and mechanism

Pending Publication Date: 2021-11-30
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of arsenic on inflammation-dominated immune diseases, especially Th2-type inflammation-dominated AD, has not been reported yet.

Method used

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  • Application of arsenic trioxide and water-soluble substances thereof in preparation of medicine for treating atopic dermatitis
  • Application of arsenic trioxide and water-soluble substances thereof in preparation of medicine for treating atopic dermatitis
  • Application of arsenic trioxide and water-soluble substances thereof in preparation of medicine for treating atopic dermatitis

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Embodiment Construction

[0013] Below in conjunction with specific embodiment, further illustrate the present invention. The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0014] 1. MC903-induced mouse AD model construction:

[0015] 1. The construction of the AD model mainly refers to "A basophil-neuronal axis promotes itch" (Cell, 2021Jan 21; 184(2):422-440.e17.) and "Calcipotriol-induced atopic dermatitis model in mice Optimum Conditions Exploration". (Chinese Pharmacology Bulletin, 2016,32(7):1027-1032). Improvements were made on this basis ( figure 1 ).

[0016] 2. 12 BALB / c mice were randomly divided into 2 groups, 2nmol MC903 dissolved in ethanol (ca...

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Abstract

The invention provides application of arsenic trioxide and water-soluble substances thereof in preparation of medicine for treating atopic dermatitis, discloses a safe and effective treatment effect of the arsenic trioxide on the atopic dermatitis (AD). The application of the arsenic trioxide and the water-soluble substances thereof in preparation of the medicine for treating the atopic dermatitis expands medical application of the arsenic trioxide, and provides a new important means for direct clinical transformation for treatment of the AD. Arsenious acid used in veins is used as a first-line medicine for treating acute promyelocytic leukemia, and compared with a biological preparation-degree priliumele injection for treating the AD at present, the cost is greatly reduced, so that the arsenious acid has important clinical significance and market prospects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of arsenic trioxide and its water solubles in the preparation of medicines for treating atopic dermatitis (AD). Background technique [0002] Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease caused by epidermal barrier damage and related immune disorders. AD is characterized by severe itching and recurrent eczema-like lesions, often associated with asthma, allergic rhinitis, food allergies and other diseases. Immune abnormality is one of the core pathogenesis of AD. It is currently recognized as an inflammatory skin disease characterized by T helper 2 (Th2) immune response phenotype. IL-4 and IL-13 are mediators of AD. An important cytokine that causes disease. Outpatient data from China showed that atopic dermatitis accounted for 7.8% of outpatient dermatology patients. The recently published "Diagnostic Criteria for Atopic Dermatitis in Chinese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/36A61P17/00A61P37/08
CPCA61K33/36A61K9/0019A61P17/00A61P37/08
Inventor 卢莹姚志荣闫金松杨伊词谭以东李忆东董轩嘉
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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