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Sparger assemblies for a bioprocessing system

A technology of biological treatment and biological treatment bags, applied in the direction of supporting/immobilizing microorganisms, biochemical instruments, chemical/physical processes, etc., can solve problems that require stability, cannot be collapsed efficiently, and are not very user-friendly

Pending Publication Date: 2021-12-21
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for single-use bioreactors, the use of multiple impellers results in bulky disposable bags that cannot be efficiently collapsed
Also, longer shafts with multiple impellers require stability, which adds complexity and cost to the vessel and bag design, and makes bag installation more cumbersome and less user friendly

Method used

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  • Sparger assemblies for a bioprocessing system
  • Sparger assemblies for a bioprocessing system
  • Sparger assemblies for a bioprocessing system

Examples

Experimental program
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Embodiment Construction

[0042] Reference will hereinafter be made in detail to exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference characters are used throughout the drawings to refer to the same or like parts.

[0043] As used herein, the terms "flexible" or "collapsible" refer to structures or materials that are flexible or capable of bending without breaking, and may also refer to materials that are compressible or expandable. An example of a flexible structure is a bag formed from polyethylene film. The terms "rigid" and "semi-rigid" are used interchangeably herein to describe structures that are "non-collapsible," that is, do not fold, collapse, or otherwise deform under normal forces to significantly reduce The structure of its elongated dimensions. Depending on the context, "semi-rigid" may also refer to structures that are more flexible than "rigid" elements, for example, bendable tubes or catheters, b...

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PUM

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Abstract

A sparger assembly (800) for a bioprocessing system includes a first layer (806) having a plurality of pores (808) of a first size, and a second layer (810) disposed above the first layer and having a plurality of holes (812) of a second size, the second size being greater than the first size. The pores of the first layer and the holes of the second layer allow for the passage of a sparge gas through the first layer and the second layer.

Description

technical field [0001] Embodiments of the invention relate generally to bioprocessing systems and methods, and more particularly to impeller and sparger assemblies for single-use bioreactor systems. Background technique [0002] A variety of vessels, devices, components, and unit operations are known for performing biochemical and / or biological processes and / or manipulating fluids and other products of such processes. To avoid the time, expense, and difficulty associated with sterilizing vessels used in biopharmaceutical manufacturing processes, single-use or disposable bioreactor bags and single-use mixer bags are used as such vessels. For example, biological material (eg, animal cells and plant cells), including, for example, mammalian cells, plant cells, or insect cells and microbial cultures, can be processed using single-use or single-use mixers and bioreactors. [0003] Increasingly, in the biopharmaceutical industry, single-use or disposable containers are used. Suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/04B01F7/00B01F13/08B01F15/00
CPCB01F2215/0431B01F23/231151B01F23/23125B01F23/231266B01F23/231231B01F23/23123B01F23/231283B01F23/23362B01F27/1111B01F33/4535B01F35/513B01F2101/44C12M29/06B01F23/2373B01F27/113B01F23/238C12M23/14C12M23/24C12M23/26C12M23/28C12M25/02
Inventor A·卡斯坦R·达姆伦
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC