Fingerprint spectrum of heart-regulating and lipid-lowering tablet and application of fingerprint spectrum in quality control

A fingerprint, lipid-lowering technology, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of difficulty in comprehensively reflecting and controlling the quality of ZJT preparations, and achieve the effects of good analysis and evaluation ability, simple method and strong specificity

Pending Publication Date: 2022-01-04
XIAN C P PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lan Richun and others established a method for the content determination of tanshinone ⅡA in ZJT; Li Zhiping and others established a quality control method for 7 components in ZJT, which made up for the lack of single-index content determination. However, these 7 components only belong to the formula It is difficult to fully reflect and control the preparation quality of ZJT

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fingerprint spectrum of heart-regulating and lipid-lowering tablet and application of fingerprint spectrum in quality control
  • Fingerprint spectrum of heart-regulating and lipid-lowering tablet and application of fingerprint spectrum in quality control
  • Fingerprint spectrum of heart-regulating and lipid-lowering tablet and application of fingerprint spectrum in quality control

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The establishment of embodiment 1 fingerprint

[0030] 1. Instruments and materials

[0031]Instruments Agilent1260 high performance liquid chromatography (Agilent, USA), Q Exactive Focus mass spectrometer (Thermo Fisher Scientific, USA); KQ-100 ultrasonic cleaning machine (Kunshan Ultrasonic Instrument Co., Ltd.); BT25S 1 / 100,000 Electronic analytical balance and BS210S 1 / 10,000 electronic analytical balance (Beijing Sartorius Scientific Instrument Co., Ltd.)

[0032] Material Zhengxin Jiangzhi Tablets (specification: 0.31g / tablet; batch numbers are 200401(S1), 200402(S2), 200403(S3), 200904(S4), 200905(S5), 200906(S6), 201208(S7 ), 201209(S8), 201210(S9), 201211(S10)) were provided by Xi’an Zhengda Pharmaceutical Co., Ltd., sheep red mutton, cassia seed, tangerine peel, Polygonum multiflorum, astragalus, salvia miltiorrhiza, kudzu root, Huai Mi were provided by Xi’an Zhengda Pharmaceutical Co., Ltd. , identified by Chen Zhiyong, an associate researcher at the Shaanx...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a fingerprint spectrum of a heart-regulating and lipid-lowering tablet and application of the fingerprint spectrum in quality control. The HPLC fingerprint spectrum of the heart-regulating and lipid-lowering tablet is established, 32 common peaks are determined, all 8 medicinal materials are covered, 26 common peak components are identified by adopting a high-resolution mass spectrometry technology, and 13 chemical components are further confirmed by comparison of a reference substance. The fingerprint spectrum method established by the invention is simple, convenient, reliable and high in specificity, provides a method and a scientific basis for quality evaluation of ZJT, and also provides a reference for further fundamental research of pharmacodynamic substances of the preparation in the future.

Description

technical field [0001] The invention belongs to the field of quality control of traditional Chinese medicines, and in particular relates to the fingerprint of Zhengxin Jiangzhi Tablet and its application in quality control. Background technique [0002] Zhengxin Jiangzhi Tablet (ZJT) is a pure Chinese medicine preparation for the treatment of coronary heart disease jointly developed by Shaanxi Academy of Traditional Chinese Medicine and Xi'an Zhengda Pharmaceutical Co., Ltd. It is now included in the 2020 edition of "Chinese Pharmacopoeia" (Part One). [0003] The functions and indications of Zhengxin Jiangzhi Tablets are replenishing qi and activating blood circulation, eliminating phlegm and reducing turbidity. It is used for qi deficiency and blood stasis, and phlegm turbidity accumulation caused by chest obstruction, heartache, headache, dizziness and other diseases. In the prescription, the monarch medicine sheep red mutton has a spicy and warm taste, has the effects of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8686G01N30/8679
Inventor 崔小敏高茂煌刘铁明陈志永晋玥媞任慧董明芝袁鹰
Owner XIAN C P PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap