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Pharmaceutical composition and application thereof

A kind of composition and medicine technology, applied in the field of medicine

Pending Publication Date: 2022-03-15
南京力博维制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent did not conduct sufficient research on specific carbapenem Klebsiella pneumoniae drug resistance. In order to overcome the technical problems of class A and class D carbapenem Klebsiella pneumoniae drug resistance in the prior art, The present invention combines cefepime and avibactam and selects the best ratio to improve the therapeutic effect

Method used

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  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] In vitro antibacterial activity verification of the present invention

[0025] 1. Test drugs and main reagents

[0026] The drugs and main reagents tested in this experiment are shown in Table 1.

[0027] Table 1 Test drugs and main reagents

[0028] serial number drug name Content% / Specification 1 Cefepime 84.5 2 Avibactam Sodium 98.9 3 Imipenem Discs 30μg / tablet 4 Imipenem Buffer /

[0029] 2. Isolation of pathogenic bacteria

[0030] Collect 17 carbapenem-resistant Escherichia coli strains and 30 carbapenem-resistant Klebsiella pneumoniae isolated from different clinical patients, and pass the bacterial identification and drug susceptibility system identification. The strains are stored in a -80°C refrigerator for future use , using American standard strain Escherichia coli ATCC25922 and Klebsiella pneumoniae ATCC700603 as quality control strains.

[0031] 3. Method

[0032] 1. In vitro sensitivity test method

[00...

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Abstract

The invention belongs to the technical field of medicine application, and particularly discloses application of a medicine composition in preparation of a medicine for inhibiting A-class or D-class carbapenem drug-resistant klebsiella pneumoniae. The pharmaceutical composition comprises a component I and a component II, the component I is cefepime or pharmaceutically acceptable salt thereof, the component II is avibactam or pharmaceutically acceptable salt thereof, the component I and the component II are mixed according to the mass ratio of 1: 1-2: 1, and the synergistic rate of the component I and the component II is as high as 95%. According to the pharmaceutical composition, the sensitivity to the carbapenem-resistant klebsiella pneumoniae can be obviously improved, the sensitivity to the A type and D type carbapenem-resistant klebsiella pneumoniae is relatively high, and the pharmaceutical composition has a good application prospect in preparation of drugs for inhibiting the A type or D type carbapenem-resistant klebsiella pneumoniae.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for inhibiting class A or class D carbapenem drug-resistant Klebsiella pneumoniae. Background technique [0002] Bacterial resistance to cephalosporins has become a serious problem at present. Strains develop resistance to currently effective antibacterial drugs, making antibacterial drugs ineffective. The consequences of this phenomenon can lead to considerable morbidity and mortality. Klebsiella pneumoniae (KPN) belongs to Gram-negative enterobacteria and is one of the most common clinical opportunistic pathogens, which can cause respiratory system, urinary system, abdominal joint and even bloodstream infection. According to reports, Klebsiella pneumoniae is the bacterium with the highest detection rate among Gram-negative bacteria, and its isolation rate in respiratory specimens occupies the fir...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/439A61P31/04
CPCA61K31/546A61K31/439A61P31/04A61K2300/00
Inventor 张峰朱素华高超肖哲媛马昀孙莉周玉梅
Owner 南京力博维制药有限公司
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