Preparation method of docetaxel and adriamycin co-loaded long-circulating liposome

Abstract

The invention discloses a preparation method of docetaxel and adriamycin co-loaded long-circulating liposome, which belongs to the technical field of medicines, and particularly comprises the following steps: reacting soybean lecithin, cholesterol, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and docetaxel together to prepare a hyaluronic membrane; then carrying out incubation treatment to obtain the docetaxel long-circulating liposome; the preparation method comprises the following steps: carrying out ultrasonic treatment, dialysis treatment and incubation treatment on docetaxel and doxorubicin to obtain a docetaxel and doxorubicin co-entrapped long-circulating liposome, and finally, carrying out dialysis treatment to obtain the docetaxel and doxorubicin co-entrapped long-circulating liposome. According to the preparation method of the docetaxel and adriamycin co-loaded long-circulating liposome, the whole process method is ingenious, docetaxel and adriamycin are creatively and jointly wrapped in the same liposome, the use effects of docetaxel and adriamycin can be well exerted, and the long-circulating liposome can be used for preparing the docetaxel and adriamycin co-loaded long-circulating liposome. And the effect in breast cancer treatment can be obviously enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a method for preparing long-circulation liposomes co-carrying docetaxel and doxorubicin. Background technique [0002] Breast cancer is a common malignant tumor clinically, its incidence rate ranks first in female malignant tumors, and its incidence rate ranks first in the world's cancer types. In my country, the incidence rate of breast cancer is increasing year by year. It poses a serious threat to the life and health of breast cancer. Because of its easy growth and transfer characteristics, the treatment results of breast cancer are not ideal. Chemotherapy is often used in the clinical treatment of advanced breast cancer, and the combined drug is often better than a single drug. In clinical practice, the combined drug of docetaxel and doxorubicin has achieved good results in the treatment of breast cancer. curative effect. [0003] Liposomes have many excellent features. The...

AI Technical Summary

Problems solved by technology

However, its water solubility is very poor, which limits its use. In clinical docetaxel injections, Tween-80 is often added as a cosolvent, and Tween-80 is easy to accumulate in the human body, which tends to cause blood vessel blockage, etc., and has harmful effects on the human body. Certain toxicity, so it is important to design a dosage form to increase water solubility, and the outer layer of liposome has a large number of hydroxyl groups, so it has good water solubility, and docetaxel is encapsulated in liposomes to increase water solubility sex is a good solution

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