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Application of picroside II in preparation of medicine for preventing and treating inflammatory bowel disease

A technology of inflammatory bowel disease and picroside, applied in the field of medicine

Pending Publication Date: 2022-05-06
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

70%-80% of CD patients have complications such as intestinal obstruction, abdominal abscess, intestinal perforation, intestinal fistula, and massive bleeding, so they may need to undergo one or more surgical treatments, which brings great pain to the patients
But now there is no report that Pic has a therapeutic effect on inflammatory bowel disease

Method used

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  • Application of picroside II in preparation of medicine for preventing and treating inflammatory bowel disease
  • Application of picroside II in preparation of medicine for preventing and treating inflammatory bowel disease
  • Application of picroside II in preparation of medicine for preventing and treating inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Experimental purpose: To illustrate the therapeutic effect of Pic on IBD by recording the weight change, diarrhea and bloody stool of mice.

[0041] Experimental design: After the model was prepared using DSS, the therapeutic effect of Pic on IBD was illustrated by daily recording of small body weight changes, diarrhea and bloody stools in each group. The result is as figure 1 , figure 2 , image 3 shown.

[0042] Result analysis: After being treated with Pic, the weight loss, diarrhea and bloody stools of the mice in the experimental group (Pic 20mg / kg group and Pic 40mg / kg group) were significantly relieved.

[0043] The results showed that: Pic can effectively treat the weight loss, diarrhea and bloody stool in mice caused by IBD.

Embodiment 2

[0045] The purpose of the experiment: To illustrate the therapeutic effect of Pic on IBD by recording the change of colon length in mice.

[0046] Experimental Design: After sacrifice, the therapeutic effect of Pic on IBD was demonstrated by recording the colon length of mice in each group. The result is as Figure 4, Figure 5 shown.

[0047] Analysis of the results: After treatment with Pic, the colon length of mice in the experimental groups (Pic 20mg / kg group and Pic 40mg / kg group) was significantly restored.

[0048] The results showed that: Pic can effectively inhibit the shortening of colon length in mice caused by IBD.

Embodiment 3

[0050] Experimental purpose: To illustrate the improvement effect of Pic on tissue damage by HE staining.

[0051] Experimental design: after sacrifice, the colon tissue of the same part of mice in each group was obtained for HE staining to illustrate the improvement effect of Pic on tissue damage. The result is as Figure 8-12 shown.

[0052] Analysis of results: After Pic treatment, the degree of colonic tissue damage in the experimental groups (Pic 20mg / kg group and Pic 40mg / kg group) was significantly improved.

[0053] The results showed that Pic can effectively improve the colonic lesions in mice caused by IBD.

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Abstract

The invention provides picroside II as a medicine for preventing and treating inflammatory bowel diseases. The invention also provides picroside II which can improve the symptoms of weight loss, diarrhea and bloody stool in the inflammatory bowel disease. The NF-kappa B pathway can be inhibited. And the expression of proinflammatory factors TNF-alpha, IL-1beta, TLR4 and COX2 can be reduced. Experimental research shows that in animal experiments, Pic can effectively relieve symptoms such as weight loss, diarrhea, occult blood stool and the like of mice caused by DSS-induced acute IBD and relieve the colon crypt destruction degree and the colon tissue inflammatory infiltration degree.

Description

technical field [0001] The invention discloses the use of berberine II in the preparation of medicines for preventing and treating inflammatory bowel disease, and belongs to the technical field of medicine. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD), including Crohn's disease (Crohn's disease, CD) and ulcerative colitis (Ulcerative colitis, UC), is a chronic, persistent intestinal Inflammatory reaction, its clinical symptoms mainly manifest as diarrhea, abdominal pain and mucus, pus and blood in the stool. Epidemiological studies have shown that the number of IBD patients in my country is on the rise. The peak incidence of CD is 18-45 years old, with a male to female ratio of 1.5:1. The prevalence of UC is about 11.6 per 100,000 people. Age range, the ratio of male to female patients is 1:1-1.3:1. 70%-80% of CD patients have complications such as intestinal obstruction, abdominal abscess, intestinal perforation, intestinal fist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/00A61P1/04A61P1/12A61P7/04A61P29/00
CPCA61K31/7048A61P1/00A61P1/04A61P1/12A61P7/04A61P29/00
Inventor 王呈呈石忠秀刘涛董嘉慧何杉
Owner GUIZHOU UNIV
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