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Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation

A Dendrobium officinale, compound preparation technology, applied in the field of traditional Chinese medicine composition, can solve the problems of lowering blood sugar, not disclosed, etc., and achieve the effect of increasing insulin secretion

Pending Publication Date: 2022-05-13
长沙智生源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two patents disclose the use of the preparations containing Dendrobium candidum, American ginseng, and wolfberry as health care products for improving immunity, but do not disclose that the compound of Dendrobium candidum, American ginseng, and wolfberry can be used to lower blood sugar

Method used

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  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation
  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation
  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Study on the impact of Dendrobium officinale compound preparation on the blood sugar of diabetic model mice

[0028] Preparation of the test article:

[0029] The compound material is mixed and crushed according to the formula ratio of Dendrobium officinale: Lycium barbarum: American ginseng is 7:2:1, and then take 200g of the mixed powder each time and put it in 2 liters of water, heat and extract in a water bath at 100°C, and then add 800mL of water to continue heating in a water bath after 2 hours 1 hour. After the extraction, cool and filter, centrifuge at 5000rpm to remove water-insoluble matter, concentrate with a rotary evaporator and freeze-dry in a vacuum, collect the freeze-dried powder and store it in a freezer at -20°C for later use.

[0030] Preparation of reference substance:

[0031] After crushing Dendrobium officinale, take 200g of the mixed powder each time and place it in 2 liters of water, heat and extract in a water bath at 100°C, add 80...

Embodiment 2

[0075] Example 2 Analysis of the effect of Dendrobium officinale compound preparation on gene expression in the liver of diabetic mice

[0076] The results of the mouse experiment showed that the effect of the compound Dendrobium candidum was better than that of the simple Dendrobium candidum, so the liver gene expression sequencing in Example 2 no longer detected the Dendrobium candidum group.

[0077] Material:

[0078] Experimental animals are the same as in Example 1. Experimental Animal Feeding and Grouping Example 1. During the mouse slaughter process, the mouse liver samples were taken in sterile enzyme-free EP tubes, and stored at -80°C until the total RNA of the samples was extracted.

[0079] Total RNA extraction and library sequencing:

[0080] The total RNA extraction and detection of mice in each experimental group were completed by Beijing Novogene Technology Co., Ltd. The sequencing process is as figure 1 :

[0081] results and analysis:

[0082] data qua...

Embodiment 3

[0115] Example 3 Effect of Dendrobium candidum compound preparation on intestinal flora of diabetic mice

[0116] The results of the mouse experiment showed that the effect of the compound Dendrobium candidum was better than that of the simple Dendrobium candidum, so the sequencing of the intestinal flora in Example 3 no longer detected the Dendrobium candidum group.

[0117] Material:

[0118] Experimental animals are the same as in Example 1. The feeding and grouping of experimental animals are the same as in Example 1. During the slaughter of the mice, the rectal feces samples of the mice were collected in sterile, enzyme-free EP tubes and stored at -80°C until fecal DNA extraction. Sequencing process

[0119]The extraction and detection of total DNA from feces of mice in each experimental group were completed by Beijing Novogene Technology Co., Ltd. The process is as follows: Figure 4 :

[0120] results and analysis:

[0121] Analysis of Dendrobium candidum compound...

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Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a dendrobium officinale compound preparation capable of reducing blood sugar as well as a preparation method and application of the dendrobium officinale compound preparation. The invention discloses a dendrobium officinale compound preparation capable of reducing blood sugar. The dendrobium officinale compound preparation is prepared from the following components: dendrobium officinale, fructus lycii and radix panacis quinquefolii. The invention further discloses a method for preparing the dendrobium officinale compound preparation. The dendrobium officinale compound preparation can play a role in reducing blood sugar, and can be applied to preparation of food, health care products or medicines for reducing blood sugar.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a compound preparation of dendrobium officinale capable of lowering blood sugar, a preparation method and an application thereof. Background technique [0002] Dendrobium officinale Kimura et Migo, an epiphyte of the genus Dendrobium orchidaceae, is a traditional precious Chinese medicinal material in my country. It has a history of edible and medicinal use for thousands of years. It was first recorded in "Shen Nong's Herbal Classic". The Tang Dynasty Taoist health preservation classic "Dao Zang" listed it as the first of the "Nine Chinese Immortal Grasses", and it is known as "Life-saving Immortal Herbs". Dendrobium officinale often grows on tree trunks or rocks in forests at an altitude of 480-1700 meters. It likes warm, humid and semi-shady environments, and is not resistant to cold, dry and stagnant water. It is mainly distributed in Guangdong, Guangxi, Yunnan, Gu...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P3/10A23L33/105
CPCA61K36/8984A61K36/258A61K36/815A61P3/10A23L33/105A61K2236/331A61K2236/39A23V2002/00A61K2300/00A23V2200/328A23V2250/21A23V2300/14
Inventor 覃思张浩伟吕承豪石萌曾朝喜
Owner 长沙智生源生物科技有限公司
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