Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation

A Dendrobium officinale, compound preparation technology, applied in the field of traditional Chinese medicine composition, can solve the problems of lowering blood sugar, not disclosed, etc., and achieve the effect of increasing insulin secretion

Pending Publication Date: 2022-05-13
长沙智生源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two patents disclose the use of the preparations containing Dendrobium candidum, American ginseng, and wolfberry as health care products f

Method used

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  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation
  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation
  • Dendrobium officinale compound preparation capable of reducing blood sugar as well as preparation method and application of dendrobium officinale compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1 Study on the effect of Dendrobium officinale compound preparation on blood sugar of diabetic model mice

[0028] Preparation of test article:

[0029] Mix and pulverize the compound materials according to the formula ratio of Dendrobium officinale: Lycium barbarum: American ginseng: 7:2:1, take 200g of the mixed powder each time and place it in 2 liters of water, heat it in a 100°C water bath for extraction, and then add 800mL of water after 2 hours to continue heating in a water bath. 1 hour. After extraction, it was cooled and filtered, centrifuged at 5000 rpm to remove water-insoluble matter, concentrated by rotary evaporator, and then vacuum freeze-dried.

[0030] Preparation of controls:

[0031] After crushing Dendrobium officinale, take 200 g of mixed powder each time and place it in 2 liters of water, heat and extract in a water bath at 100°C, and then add 800 mL of water for 2 hours and continue heating in a water bath for 1 hour. After extraction,...

Example Embodiment

[0075] Example 2 Analysis of the effect of Dendrobium officinale compound preparation on liver gene expression in diabetic mice

[0076] The results of the mouse test showed that the compound effect of Dendrobium officinale was better than the effect of simple Dendrobium officinale, so the liver gene expression sequencing of Example 2 no longer detected the Dendrobium officinale group.

[0077] Material:

[0078] The experimental animals were the same as those in Example 1. Experimental animal feeding and grouping Example 1. During the slaughtering process, the mouse liver samples were taken in sterile non-enzyme EP tubes and stored at -80°C until total RNA extraction of the samples.

[0079] Total RNA extraction and library sequencing:

[0080] The extraction and detection of total RNA of mice in each experimental group was completed by Beijing Nuohezhiyuan Technology Co., Ltd. Sequencing process such as figure 1 :

[0081] results and analysis:

[0082] Data quality c...

Example Embodiment

[0115] Example 3 Influence of Dendrobium officinale compound preparation on intestinal flora of diabetic mice

[0116] The results of the mouse test show that the compound effect of Dendrobium officinale is better than the effect of simple Dendrobium officinale, so the intestinal flora sequencing of Example 3 no longer detects the Dendrobium officinale group.

[0117] Material:

[0118] The experimental animals were the same as those in Example 1. The feeding and grouping of experimental animals were the same as those in Example 1. During the slaughter of mice, fecal samples from the mouse rectum were taken in sterile non-enzyme EP tubes and stored at -80°C until fecal DNA extraction was performed. Sequencing process

[0119]The extraction and detection of total DNA from feces of mice in each experimental group was completed by Beijing Nuohezhiyuan Technology Co., Ltd. The process is as follows Figure 4 :

[0120] results and analysis:

[0121] Diversity of intestinal m...

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Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a dendrobium officinale compound preparation capable of reducing blood sugar as well as a preparation method and application of the dendrobium officinale compound preparation. The invention discloses a dendrobium officinale compound preparation capable of reducing blood sugar. The dendrobium officinale compound preparation is prepared from the following components: dendrobium officinale, fructus lycii and radix panacis quinquefolii. The invention further discloses a method for preparing the dendrobium officinale compound preparation. The dendrobium officinale compound preparation can play a role in reducing blood sugar, and can be applied to preparation of food, health care products or medicines for reducing blood sugar.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a compound preparation of dendrobium officinale capable of lowering blood sugar, a preparation method and an application thereof. Background technique [0002] Dendrobium officinale Kimura et Migo, an epiphyte of the genus Dendrobium orchidaceae, is a traditional precious Chinese medicinal material in my country. It has a history of edible and medicinal use for thousands of years. It was first recorded in "Shen Nong's Herbal Classic". The Tang Dynasty Taoist health preservation classic "Dao Zang" listed it as the first of the "Nine Chinese Immortal Grasses", and it is known as "Life-saving Immortal Herbs". Dendrobium officinale often grows on tree trunks or rocks in forests at an altitude of 480-1700 meters. It likes warm, humid and semi-shady environments, and is not resistant to cold, dry and stagnant water. It is mainly distributed in Guangdong, Guangxi, Yunnan, Gu...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P3/10A23L33/105
CPCA61K36/8984A61K36/258A61K36/815A61P3/10A23L33/105A61K2236/331A61K2236/39A23V2002/00A61K2300/00A23V2200/328A23V2250/21A23V2300/14
Inventor 覃思张浩伟吕承豪石萌曾朝喜
Owner 长沙智生源生物科技有限公司
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