Application of traditional Chinese medicine composition in preparation of anti-SARS (severe acute respiratory syndrome) virus medicine

A composition and technology of traditional Chinese medicine, applied in the application field of anti-SARS virus, can solve the undisclosed anti-SARS virus and other problems

Pending Publication Date: 2022-07-08
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent application No. 202010153827.1 discloses that this Chinese medicine composition has anti-influenza virus and anti-new coronavirus effects, but it does not disclose that this Chinese medicine composition has anti-SARS virus effects

Method used

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  • Application of traditional Chinese medicine composition in preparation of anti-SARS (severe acute respiratory syndrome) virus medicine
  • Application of traditional Chinese medicine composition in preparation of anti-SARS (severe acute respiratory syndrome) virus medicine
  • Application of traditional Chinese medicine composition in preparation of anti-SARS (severe acute respiratory syndrome) virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] prescription:

[0058] Ephedra 52 grams; Gypsum 324 grams; Forsythia 194 grams; Scutellaria baicalensis 78 grams; Morus alba 194 grams; Bitter almonds 130 grams; Qian Hu 78 grams; Pinellia 130 grams; 130 grams; 130 grams of silver flower; 39 grams of rhubarb; 76 grams of bellflower; 65 grams of licorice.

[0059] Preparation:

[0060] A. Weigh Fritillaria fritillary according to the proportion of the formula, pulverize it into fine powder, and set aside;

[0061] B. Weigh ephedra, forsythia, bitter almond, pinellia, burdock, rhubarb and 50% ethanol for reflux extraction 2 times according to the proportion of the prescription, each time for 3 hours, add 10 times the amount for the first time, and add 6 times for the second time. times, the extracts were combined, filtered, the filtrate was decompressed to recover ethanol, and concentrated to a clear paste with a thermal relative density of 1.15 at 60°C for later use;

[0062] C. Weigh gypsum, mulberry white skin, Qian...

Embodiment 2

[0066] prescription:

[0067] Ephedra 86 grams; Gypsum 194 grams; Forsythia 324 grams; Scutellaria baicalensis 130 grams; Mulberry white skin 324 grams; Fried bitter almonds 78 grams; 78 grams; 78 grams of silver flower; 65 grams of rhubarb; 46 grams of bellflower; 39 grams of licorice.

[0068] Preparation:

[0069] A. Weigh the Fritillaria according to the proportion of the formula, pulverize it into fine powder, and set aside;

[0070] B. Weigh ephedra, forsythia, fried bitter almond, pinellia, burdock, rhubarb and 40% ethanol for reflux extraction 2 times according to the proportion of the prescription, each time for 4 hours, add 8 times the amount for the first time, add 8 times the amount for the second time 9 times the amount, the extracts were combined, filtered, the filtrate was decompressed to recover ethanol, and concentrated to a clear paste with a thermal relative density of 1.14 at 60°C for later use;

[0071] C. Weigh gypsum, mulberry white skin, Qianhu, drie...

Embodiment 3

[0075] prescription:

[0076] Ephedra 69 grams; Gypsum 259 grams; Forsythia 259 grams; Scutellaria baicalensis 104 grams; Mulberry white skin 259 grams; Fried bitter almonds 104 grams; 104 grams of burdock seeds; 104 grams of silver flower; 52 grams of rhubarb; 61 grams of Campanulaceae; 52 grams of licorice.

[0077] Preparation:

[0078] A. Weigh Fritillaria fritillary according to the proportion of the formula, pulverize it into fine powder, and set aside;

[0079] B. Weigh ephedra, forsythia, fried bitter almond, pinellia chinensis, burdock seed, rhubarb and 70% ethanol for reflux extraction 2 times according to the proportion of the formula, each time for 1 hour, add 10 times the amount for the first time, and the second time Add 6 times the amount, the extracts are combined, filtered, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a thermal relative density of 1.16 at 60°C for later use;

[0080] C. Weigh gypsum, mulberry white...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for inhibiting SARS (severe acute respiratory syndrome) virus. The traditional Chinese medicine composition is mainly composed of ephedra, gypsum, fructus forsythiae, scutellaria baicalensis, white mulberry root-bark, semen armeniacae amarae, radix peucedani and the like, the overall regulation advantage of the compound traditional Chinese medicine is exerted, the traditional Chinese medicine composition has the characteristics of multidirectivity, multi-level and multi-target, in-vivo and in-vitro experiments prove that the traditional Chinese medicine composition can effectively kill SARS viruses, and the effect is remarkable.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in the preparation of antiviral drugs, in particular to the application of anti-SARS virus, and belongs to the field of Chinese herbal medicine. Background technique [0002] SARS virus belongs to the coronavirus family (coronaviridae). Most of the virus particles are round, with a capsule, and there are fibrils arranged in a crown on the periphery. They are distributed in the cytoplasm and are circular. The diameter of the virus is between 80 and 120 nm. SARS virus is a variant of coronavirus, the pathogen that causes SARS. Variant coronavirus is related to influenza virus, but it is a very unique type of coronavirus. This is the culprit behind the severe acute respiratory syndrome (SARS, SARS) that ravaged the world from the winter of 2002 to the spring of 2003. Coronavirus. [0003] The SARS virus is extremely common around the world. About 15 different strains...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/00A61P31/14A61K33/06
CPCA61K36/17A61K33/06A61K36/634A61K36/539A61K36/605A61K36/736A61K36/23A61K36/8888A61K36/752A61K36/8966A61K36/28A61K36/355A61K36/708A61K36/346A61K36/484A61P31/14A61P11/00A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00A61P31/12A61K9/20A61K9/00A61K9/12
Inventor 贾振华
Owner SHIJIAZHUANG YILING PHARMA
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