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Application of intestinal Rosebariella in preparation of tumor radiosensitizer

A radiosensitizer, the technology of Bairyella, which is applied in the field of Rosbyella enterica in the preparation of radiosensitizers for colorectal cancer, can solve the difference in the sensitivity of tumor cells to radiation, affect the actual effect of radiotherapy, Radiosensitizers cannot effectively meet the clinical needs of radiotherapy and other problems, and achieve the effect of reducing the level of intestinal inflammation, reducing the degree of inflammation, and reducing the volume

Pending Publication Date: 2022-07-15
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the technical problems existing in the prior art, for example, the sensitivity of tumor cells to radiation has a large difference, which affects the actual effect of radiotherapy, and the existing radiosensitizers cannot effectively meet the clinical needs of radiotherapy, The present invention provides the use of Rosborella enterica in the preparation of radiosensitizers for tumors

Method used

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  • Application of intestinal Rosebariella in preparation of tumor radiosensitizer
  • Application of intestinal Rosebariella in preparation of tumor radiosensitizer
  • Application of intestinal Rosebariella in preparation of tumor radiosensitizer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1: Detection of the effect of bacterial species on the number and volume of tumors in the large intestine of mice

[0066] 1. Experimental animals:

[0067] C57BL / 6J male mice, 6-8 weeks old, weighing about 20 g. Mice were randomly divided into three groups according to body weight, namely: blank control group, simple irradiation group, and irradiation + intestinal Rosbyella administration group.

[0068] 2. Model establishment:

[0069] (1) To establish a mouse model of colorectal cancer induced by the mutagen azomethane (AOM) and the inflammatory agent dextran sulfate sodium (DSS), such as figure 1 As shown, AOM (10 mg / kg) was injected intraperitoneally on the 0th day, 1.5% DSS was fed after 1 week, and after 7 consecutive days, normal water was fed for 2 weeks, which was a cycle, a total of 3 cycles.

[0070] (2) After anesthetizing the experimental mice with 0.3% chloral hydrate (the anesthetic dose is 1ml / g), use 40Exactor was used to irradiate the ...

Embodiment 2

[0080] Example 2: Detecting the effect of bacterial species on the number and volume of tumors in the large intestine of mice

[0081] 1. Experimental animals:

[0082] C57BL / 6J male mice, 6-8 weeks old, weighing about 20 g. Mice were randomly divided into three groups according to body weight, namely: blank control group, simple irradiation group, and irradiation + intestinal Rosbyella administration group.

[0083] 2. Model establishment:

[0084] (1) To establish a mouse model of colorectal cancer induced by the mutagen azomethane (AOM) and the inflammatory agent dextran sulfate sodium (DSS), such as figure 1 As shown, AOM (10 mg / kg) was injected intraperitoneally on the 0th day, 1.5% DSS was fed after 1 week, and after 7 consecutive days, normal water was fed for 2 weeks, which was a cycle, a total of 3 cycles.

[0085] (2) After anesthetizing the experimental mice with 0.3% chloral hydrate (the anesthetic dose is 1ml / g), use 40Exactor was used to irradiate the whole...

Embodiment 3

[0095] Example 3: Detecting the effect of bacterial species on the number and volume of tumors in the large intestine of mice

[0096] 1. Experimental animals:

[0097] C57BL / 6J male mice, 6-8 weeks old, weighing about 20 g. Mice were randomly divided into three groups according to body weight, namely: blank control group, simple irradiation group, and irradiation + intestinal Rosbyella administration group.

[0098] 2. Model establishment:

[0099] (1) To establish a mouse model of colorectal cancer induced by the mutagen azomethane (AOM) and the inflammatory agent dextran sulfate sodium (DSS), such as figure 1 As shown, AOM (10 mg / kg) was injected intraperitoneally on the 0th day, 1.5% DSS was fed after 1 week, and after 7 consecutive days, normal water was fed for 2 weeks, which was a cycle, a total of 3 cycles.

[0100] (2) After anesthetizing the experimental mice with 0.3% chloral hydrate (the anesthetic dose is 1ml / g), use 40Exactor was used to irradiate the who...

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Abstract

The invention belongs to the technical field of medicines, and relates to application of intestinal Rosebariella in preparation of a tumor radiosensitizer. Research finds that the Roseburia intestinae can significantly improve the sensitivity of colorectal cancer to radiotherapy, which shows that after a colorectal cancer model mouse subjected to intragastric administration by the Roseburia intestinae is subjected to radiotherapy, the number of nodule is reduced, the size is reduced, the proliferation inhibition effect of colorectal cancer cells is improved, and the Roseburia intestinae can be used for preparing a colorectal cancer model mouse with the Roseburia intestinae. And the inflammation degree of the intestinal tract of the mouse subjected to local abdominal irradiation is reduced, so that the intestinal Rosiberia can be used as a tumor radiosensitizer, and the intestinal inflammation level is reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the use of R. enterica in preparing a radiosensitizer for tumors, in particular to the use of R. enterica in preparing a radiosensitizer for colorectal cancer. Background technique [0002] Digestive system tumors include esophageal cancer, gastric cancer, liver cancer, pancreatic cancer and colorectal cancer, etc., with high incidence, hidden onset, limited diagnosis and treatment methods, and a serious threat to human health. Among them, colorectal cancer (CRC), also known as colorectal cancer, rectal cancer, colorectal cancer, colorectal cancer or bowel cancer, is a cancer originating from the colon or rectum (which is a part of the large intestine), and is the most common cancer in the digestive tract. One of the common malignant tumors. According to the 2019 report on the number of new cases and deaths from the top ten major cancer types in the United States, colorectal canc...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K45/06A61P35/00B82Y5/00
CPCA61K35/74A61K45/06A61P35/00B82Y5/00
Inventor 崔明董佳丽李源肖惠文王滨张书琴
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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