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Medicament capable of improving central nervous system inflammation

A central nervous system and inflammation technology, applied in the direction of nervous system diseases, non-central analgesics, anti-inflammatory agents, etc., can solve problems such as large side effects, achieve the effect of reducing the content, increasing the level, and increasing the survival rate

Pending Publication Date: 2022-07-22
西安市胸科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine is the main treatment, and the side effects are relatively large. Therefore, it is necessary to develop a traditional Chinese medicine preparation that is more effective than Western medicine and can improve central nervous system inflammation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A medicament for improving inflammation of the central nervous system, when preparing, weighed in parts by weight: 10 parts of Scutellaria baicalensis, 10 parts of Coptis chinensis, 10 parts of Perilla frutescens, 5 parts of Gardenia, 10 parts of Amaryllis seeds, 10 parts of Rehmannia glutinosa, Radix Astragali 5 parts, 5 parts of safflower, 5 parts of ginsenosides, 10 parts of sea cucumber peptides; the weighed Scutellaria baicalensis, Coptis chinensis, Perilla frutescens, gardenia, yellow sunflower seeds, Rehmannia glutinosa, Astragalus, and safflower are ultrafinely crushed to 200 mesh. , placed in the enzymolysis tank, heated 6 times the amount of water, and adjusted the pH to 6.0, added 10% α-amylase of the slurry, stirred and liquefied at 60°C for 45min, cooled to 55°C, adjusted the pH to 4.5, added Cellulase with a slurry content of 10%, keep stirring for 60 minutes, and after high temperature inactivate the enzyme, dry to a water content of about 10%, mix with gi...

Embodiment 2

[0021] A medicament for improving inflammation of the central nervous system, when preparing, weighed in parts by weight: 20 parts of Scutellaria baicalensis, 15 parts of Coptis chinensis, 15 parts of Perilla frutescens, 15 parts of Gardenia, 20 parts of Amaryllis seeds, 15 parts of Rehmannia glutinosa, Radix Astragali 10 parts, 6 parts of safflower, 10 parts of ginsenosides, 20 parts of sea cucumber peptide; Scutellaria baicalensis, Coptis chinensis, Perilla frutescens, gardenia, yellow sunflower seeds, Rehmannia glutinosa, Astragalus, and safflower were superfinely pulverized to 200 mesh. , placed in the enzymolysis tank, heated 6 times the amount of water, and adjusted the pH to 6.0, added 10% α-amylase of the slurry, stirred and liquefied at 60°C for 45min, cooled to 55°C, adjusted the pH to 4.5, added Cellulase with a slurry content of 10%, keep stirring for 60 minutes, and after high temperature inactivate the enzyme, dry to a water content of about 10%, mix with ginsenos...

Embodiment 3

[0023] A medicament for improving inflammation of the central nervous system, when preparing, weighed in parts by weight: 15 parts of Scutellaria baicalensis, 12.5 parts of Coptis chinensis, 12.5 parts of Perilla frutescens, 10 parts of Gardenia, 15 parts of Amaryllis seeds, 12.5 parts of Rehmannia glutinosa, Radix Astragali 7.5 parts, 5.5 parts of safflower, 7.5 parts of ginsenosides, 15 parts of sea cucumber peptide; Scutellaria baicalensis, Coptis chinensis, Perilla frutescens, gardenia, yellow sunflower seeds, Rehmannia glutinosa, Astragalus, and safflower were superfinely pulverized to 200 mesh. , placed in the enzymolysis tank, heated 6 times the amount of water, and adjusted the pH to 6.0, added 10% α-amylase of the slurry, stirred and liquefied at 60°C for 45min, cooled to 55°C, adjusted the pH to 4.5, added Cellulase with a slurry content of 10%, keep stirring for 60 minutes, and then inactivate the enzyme at high temperature, dry to a water content of about 10%, mix w...

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PUM

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Abstract

The invention relates to the field of traditional Chinese medicine preparations, in particular to a medicament for improving central nervous system inflammation, which is prepared from the following raw materials in parts by weight: 10-20 parts of scutellaria baicalensis, 10-15 parts of coptis chinensis, 10-15 parts of perilla frutescens, 5-15 parts of gardenia, 10-20 parts of abelmoschus esculentus seeds, 10-15 parts of radix rehmanniae recen, 5-10 parts of astragalus membranaceus, 5-6 parts of safflower carthamus, 5-10 parts of ginsenoside and 10-20 parts of sea cucumber peptide. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, removing blood stasis, stimulating menstrual flow, diminishing inflammation and resisting viruses, can up-regulate various neurotransmitters, obviously increase the brain IL-13 level and obviously increase the survival rate of PC12 cells, and meanwhile can obviously reduce the content of TNF-alpha and IL-1beta.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a medicament for improving inflammation of the central nervous system. Background technique [0002] Inflammation of the central nervous system is an important pathological feature of a variety of central nervous system diseases, including neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, etc.), depression, postoperative cognitive dysfunction, schizophrenia. disease, etc. At present, western medicine is the main treatment, and the side effects are relatively large. Therefore, it is necessary to develop a traditional Chinese medicine preparation that has better efficacy than western medicine and can improve the inflammation of the central nervous system. SUMMARY OF THE INVENTION [0003] The present invention provides a medicament for improving the inflammation of the central nervous system, which can effectively...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61P25/00A61P29/00A61K36/804
CPCA61K36/539A61K36/718A61K36/535A61K36/744A61K36/185A61K36/804A61K36/481A61K36/286A61K36/258A61K38/02A61P25/00A61P29/00A61K2300/00
Inventor 胡明军
Owner 西安市胸科医院
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