Heart failure marker multi-parameter detection device and method based on smart phone

A technology of a smart phone and a detection device is applied in the fields of image processing, biological immune technology, nanomaterials, and immune sensors. The effect of portable instrument

Pending Publication Date: 2022-07-29
ZHEJIANG UNIV +1
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Problems solved by technology

At present, large-scale automatic biochemical analyzers are usually used for the detection and analysis of heart disease markers in blood. T

Method used

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  • Heart failure marker multi-parameter detection device and method based on smart phone
  • Heart failure marker multi-parameter detection device and method based on smart phone
  • Heart failure marker multi-parameter detection device and method based on smart phone

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Embodiment Construction

[0047] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments, but it is not intended to limit the present invention.

[0048] like Figure 1-Figure 4 As shown in the figure, the present invention provides a multi-parameter detection device for heart failure markers based on a smart phone. The device includes a fluorescent immunoassay test strip and a fluorescent detection instrument, and can perform multi-parameter simultaneous quantitative detection on the fluorescent immunoassay test strip, thereby Obtain the concentration of the marker in the sample.

[0049] The fluorescent immunoassay strip includes: 3mm*22mm sample pad (glass fiber pad), 3mm*25mm nitrocellulose membrane (NC membrane), 3mm*16mm absorbent pad and 3mm*60mm PVC (polyvinyl chloride) ) bottom plate; wherein, the PVC bottom plate is located on the bottom layer, and the sample pad, NC film, and water-absorbing pad are pasted on the P...

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Abstract

The invention discloses a heart failure marker multi-parameter detection device and method based on a smart phone. The device comprises a fluorescence immunoassay test strip and a fluorescence detection instrument. The fluorescence immunoassay test strip is composed of a PVC base plate, a sample pad, a nitrocellulose membrane (NC membrane) and a water absorption pad. The fluorescence detection instrument is composed of a smart phone, a top plate, a darkroom, an instrument bottom plate, a lens, an optical filter, an optical filter clamping groove, an ultraviolet LED, an LED support, a power supply and a power supply charging circuit. A slot is formed in the rear part of the fluorescence detection instrument, a smart phone card slot is formed in the top plate, a fluorescence immune test strip is inserted from the slot, a smart phone is inserted from the smart phone card slot, and the smart phone takes a picture of the test strip and analyzes and processes a collected image. According to the invention, the detection limit of the BNP is 0.03 ng/mL, and the detection range is 0.1-7.5 ng/mL; the detection limit of the NT-proBNP is 0.095 ng/mL, and the detection range of the NT-proBNP is 0.1 to 7.5 ng/mL; the detection limit of ST2 is 4.492 ng/mL, and the detection range is 5-400 ng/mL.

Description

technical field [0001] The invention relates to the fields of immune sensors, biological immune technology, nanomaterials, image processing and the like, in particular to a multi-parameter detection device and method for heart failure markers based on smart phones. Background technique [0002] Quantum dots (QDs), as a new type of fluorescent labeling materials, are characterized by their tunable emission spectrum, large Stokes shift, strong photostability, broad excitation spectrum and narrow emission spectrum, and biological phase. It is widely used to improve the detection sensitivity of immunochromatography due to its advantages of good capacitance and long fluorescence lifetime. Quantum-dot submicrobeads (QBs) further enhance the fluorescence intensity by encapsulating a large number of quantum dots in polymer microspheres, and further enhance the optical and solution stability of QBs due to the encapsulation of the polymer shell. Therefore, it is often used as an anti...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N33/53
CPCG01N21/6428G01N33/53G01N2021/6439
Inventor 王平李丰恒刘鑫孔留兵万浩
Owner ZHEJIANG UNIV
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