Traditional Chinese medicine as well as preparation method and application thereof in preparation of medicine for treating hashimoto thyroiditis

A technology of traditional Chinese medicine and liquid medicine, which is applied in the direction of medical formula, drug combination, plant raw materials, etc., can solve the problems that cannot be cured at its root, and achieve a significant curative effect

Active Publication Date: 2022-08-05
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of traditional Chinese medicine and its preparation method and its application in the preparation of medicines for treating Hashimoto’s thyroiditis, which is used to solve the fundamental problem that HT-related Chinese medicine prescriptions in the prior art cannot cure its fundamental problem, and provide Chinese patent medicines for the treatment of Hashimoto’s thyroiditis. This thyroiditis provides research basis

Method used

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  • Traditional Chinese medicine as well as preparation method and application thereof in preparation of medicine for treating hashimoto thyroiditis
  • Traditional Chinese medicine as well as preparation method and application thereof in preparation of medicine for treating hashimoto thyroiditis
  • Traditional Chinese medicine as well as preparation method and application thereof in preparation of medicine for treating hashimoto thyroiditis

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preparation example Construction

[0034] The preparation raw materials of the traditional Chinese medicine composition provided by the present invention comprise 0.5-1.5 parts of lily, preferably 0.7-1.3 parts, and more preferably 0.8-1.2 parts.

[0035] The preparation raw materials of the traditional Chinese medicine composition provided by the present invention comprise 1-3 parts of hemp seeds, preferably 1.5-2.5 parts, more preferably 1.9-2.1 parts.

[0036] The preparation raw materials of the traditional Chinese medicine composition provided by the present invention comprise 3-5 parts of Ophiopogon japonicus, preferably 3.5-4.5 parts, more preferably 3.8-4.3 parts.

[0037] The preparation raw materials of the traditional Chinese medicine composition provided by the present invention comprise 1-3 parts of black plum, preferably 1.3-2.7 parts, more preferably 1.6-2.2 parts.

[0038] The preparation raw materials of the traditional Chinese medicine composition provided by the present invention comprise 1-3...

Embodiment 1

[0054] Take 10g of lily, soak 100ml of 95% ethanol in a clean beaker, seal it with plastic wrap, place it in a dry and cool place away from light, shake and stir twice a day, and after soaking for 7 days, filter the medicinal solution with a negative pressure of -0.05MPa to In the funnel bottle, pour the filtered medicinal liquid into a rotary evaporator, and use a rotary evaporator to perform low-temperature rotary evaporation at 56 °C, a vacuum negative pressure of -0.09 MPa, and a medium rotation speed. When the medicinal liquid is rotary evaporated to 5ml, close the rotary evaporator , pour the medicinal liquid into an evaporating dish, evaporate it in a 56 ℃ water bath for 2 days, put it in a vacuum drying oven at 56 ℃ and a vacuum degree of -0.09MPa for drying treatment, scrape and mix the dried medicine and fully dissolve it in dimethyl methylene sulfone (DMSO) to prepare 0.3 g / mL lily extract.

[0055] Take 20g of hemp seeds, soak 200ml of 95% ethanol in a clean beaker...

Embodiment 2

[0061] Take 8g of lily, take 100ml of 95% ethanol and soak it in a clean beaker, seal it with plastic wrap, place it in a dry and cool place away from light, shake and stir twice a day, soak for 7 days, and filter the medicinal solution with a negative pressure of -0.05MPa to In the funnel bottle, pour the filtered medicinal liquid into a rotary evaporator, and use a rotary evaporator to perform low-temperature rotary evaporation at 56 °C, a vacuum negative pressure of -0.09 MPa, and a medium rotation speed. When the medicinal liquid is rotary evaporated to 5ml, close the rotary evaporator , pour the medicinal liquid into an evaporating dish, evaporate it in a 56 ℃ water bath for 2 days, put it in a vacuum drying oven at 56 ℃ and a vacuum degree of -0.09MPa for drying treatment, scrape and mix the dried medicine and fully dissolve it in dimethyl methylene sulfone (DMSO) to prepare 0.3 g / mL lily extract.

[0062] Take 13g of hemp seeds, soak 200ml of 95% ethanol in a clean beak...

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Abstract

The invention provides a traditional Chinese medicine, a preparation method thereof and application of the traditional Chinese medicine in preparation of a medicine for treating hashimoto thyroiditis, belongs to the technical field of traditional Chinese medicines, solves the problem that HT related traditional Chinese medicine formulas in the prior art cannot treat the basis of the traditional Chinese medicine, and provides a research basis for treating hashimoto thyroiditis by Chinese patent medicines. The traditional Chinese medicine composition is composed of lily, fructus cannabis, radix ophiopogonis, fructus mume and radix ampelopsis, the five traditional Chinese medicines have a synergistic protection effect on a TPOAb damaged thyroid follicular cell model, the protection effect of the five traditional Chinese medicines on the cell model is possibly related to cell apoptosis inhibition, the content of T4 secreted by the cell model is remarkably increased after action, and the five traditional Chinese medicines have a synergistic effect; clinical experiments show that the traditional Chinese medicine composition provided by the invention is remarkably superior to a control group in the aspect of improving traditional Chinese medicine syndrome scores, and has a remarkable curative effect on hashimoto thyroiditis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine, a preparation method thereof and an application in the preparation of a medicine for treating Hashimoto's thyroiditis. Background technique [0002] Hashimoto's thyroiditis (HT) is an autoimmune disease of the thyroid gland, also known as chronic lymphocytic thyroiditis. disease. According to literature reports, the incidence of autoimmune thyroid disease in foreign countries is 2-5%, with a male-to-female ratio of 1:8-15, and most occurs in 30-60 years old; the exact incidence of Hashimoto's thyroiditis in China is not clear, about 7.3% to 20.5% of the disease, the ratio of male to female is 1:6 to 10, and it is more common in women aged 30 to 50. Hashimoto's disease has an insidious onset, a slow development, and a long course of disease. Its pathological features are lymphocyte infiltration in the thyroid tissue, follicula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P37/02
CPCA61K36/8967A61K36/60A61K36/8968A61K36/736A61K36/87A61P37/02A61K2236/333A61K2236/53A61K2236/51A61K2300/00Y02A50/30
Inventor 司富春宋雪杰刘子提司高司季青
Owner HENAN UNIV OF CHINESE MEDICINE
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