Application of gentiopicrin in preparing medication for restraining hepatitis B virus
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A technology of hepatitis B virus and gentiopicroside, which is applied in the direction of antiviral agents, drug combinations, and pharmaceutical formulas, and can solve the problems of long medication cycle, slow effect, and large toxic and side effects
Inactive Publication Date: 2006-06-14
HARBIN GLORIA PHARMA CO LTD
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Problems solved by technology
[0005] At present, Western medicine has certain effects on the treatment of hepatitis B, but it has the disadvantages of large toxic and side effects and high recurrence rate.
The effect of traditional Chinese medicine treatment is slow. It takes a month or even a few months to feel whether it is effective. The medication cycle is very long. Some patients take the medicine for several years. Long-term medication is very irritating to the stomach. Many patients lose their diet and lose weight. curative effect is uncertain
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Embodiment 1
[0016] The pharmaceutical preparation gentiopicroside is prepared into tablets, taking the production of 1000 tablets as an example, the raw materials and auxiliary materials and their weight ratios are as follows:
[0017] Gentiopicroside 200g
[0018] Starch 100g
[0019] Its preparation process is carried out according to the conventional process of pharmacy tablets, each tablet weighs 0.3g, and each tablet contains gentiopicroside 200mg.
[0020] Dosage: Take orally, 1 tablet each time, once a day, reduce as appropriate for children, 30 days is a course of treatment.
Embodiment 2
[0022] The medicinal preparation gentiopicroside is prepared into capsules, taking the production of 1000 capsules as an example, the raw materials and auxiliary materials and their weight ratios are as follows:
[0023] Gentiopicroside 200g
[0024] Starch 100g
[0025] Its preparation process is carried out according to the conventional process of pharmaceutical capsules, each capsule weighs 0.3g, and each capsule contains 200mg of gentiopicroside.
[0026] Usage and dosage: take orally, 1 capsule each time, once a day, reduce it for children. 30 days is a course of treatment.
Embodiment 3
[0028] The medicinal preparation gentiopicroside is prepared into granules, taking the production of 1000g of granule products as an example, the raw materials and auxiliary materials and their weight ratios are as follows:
[0029] Gentiopicroside 200g
[0030] Sucrose 400g
[0031] Dextrin 400g
[0032] The preparation process is carried out according to the conventional process of pharmacy granules, each bag weighs 1g, and 1g contains gentiopicroside 200mg.
[0033] Usage and dosage: Take orally, 1 bag each time, once a day, reduce it for children. 30 days is a course of treatment.
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Abstract
The application of the active ingredient gentiopicroside in the preparation of drugs for inhibiting hepatitis B virus. The active ingredient gentiopicroside is a compound extracted and separated from the commonly used traditional Chinese medicine Gentiana quinquefolium in my country. The active ingredient gentiopicroside is mixed with pharmaceutically acceptable carriers in preparations such as those suitable for enteral and parenteral administration. Organic or inorganic solid or liquid excipients are mixed, and the pharmaceutical preparation can be in solid form such as tablet, capsule, powder, pill, granule, or in liquid form such as injection, emulsion, etc. Gentiopicroside was prepared into injections, and the drug efficacy test showed that ducks infected with duck hepatitis B virus were treated with intramuscular injection of gentiopicroside on the 7th day after infection. The inhibitory effect of duck serum DHBV-DNA level is remarkable, and the statistical processing results have very significant and significant differences, inhibitory effect (P<0.01-0.05), and the inhibitory effect of three batches of experiments can be repeated.
Description
technical field [0001] The invention relates to the new application of gentiopicroside for inhibiting hepatitis B virus in the body. Background technique [0002] The treatment of viral diseases has always been a difficult problem in the medical field. Although human beings defeated infectious diseases caused by bacteria in the nineteenth century, diseases caused by viral infections, such as AIDS, SARS, influenza, hepatitis B, meningitis, myocarditis, herpes zoster, etc., have not been cured so far. Fang, has been in the process of exploration. [0003] More prominent is hepatitis B. my country is the largest hepatitis country in the world. There are about 200 million virus carriers, about 120 million patients, and about 40 million hospitalized patients, which has aroused widespread concern in the medical field. [0004] The treatment of hepatitis B is divided into three aspects: inhibiting the virus, protecting the liver and promoting gallbladder, and reducing enzymes. T...
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