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Dogwood extraction and its preparation method and usage

A technology of extract and cornus, applied in the field of cornus extract, can solve the problems such as prevention and treatment of diabetic vascular disease that have not been seen with cornus extract, and achieve the effects of improving the morphological and pathological changes of vascular endothelium and kidney tissue, reducing the amount of excretion and lowering blood sugar.

Active Publication Date: 2006-06-14
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, so far, there has not been a preparation process for simultaneously obtaining the two effective parts of the total iridoid glycosides and the total triterpene acids of Cornus officinalis, and there has been no report on the use of Cornus officinalis extracts for the preparation of drugs for preventing and treating diabetic vascular disease and lowering blood sugar.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] 1000 g of Cornus officinalis medicinal material was reflux extracted with ethanol for 3 times, the ethanol concentration was 70%, the amount of alcohol added was 15 times of the weight of the medicinal material, the extraction time was 120 min, and the extraction temperature was 80°C. The extracts were combined, filtered and concentrated under reduced pressure. The concentrated solution was added with 4 times the amount of water to precipitate and then centrifuged. The precipitate was collected and dried under reduced pressure, crushed to obtain extract A, and the centrifuged supernatant was concentrated under reduced pressure for later use.

[0097] Take the non-polar macroporous adsorption resin, pack it into a column at a ratio of 1:1 to the weight ratio of the crude drug, and then pass the above-mentioned concentrated solution for use through the macroporous resin column at a flow rate of 1 column volume / hour. Deionized water was used for elution, followed by gradien...

Embodiment 2

[0100] 1000 g of Cornus officinalis medicinal material was reflux extracted twice with ethanol, the ethanol concentration was 85%, the amount of alcohol added was 12 times of the weight of the medicinal material, the extraction time was 90 min, and the extraction temperature was 75°C. Combine the extracts, filter and concentrate under reduced pressure, add 5 times the amount of water to the concentrate to precipitate, then centrifuge, collect the precipitate, dry it under reduced pressure, pulverize to obtain extract A, and concentrate the supernatant under reduced pressure for future use.

[0101] Take a medium-polarity macroporous adsorption resin, pack it into a column at a ratio of 1:2 to the weight ratio of the crude drug, and then pass the above-mentioned standby concentrated solution through the macroporous resin column at a flow rate of 1.5 column volume / hour. After passing through completely, use Deionized water was used for elution, followed by gradient elution with 5...

Embodiment 3

[0104] 1000 g of cornus officinalis is crushed and passed through a 40-mesh sieve, impregnated with 20% ethanol for 48 hours, and then extracted by percolation at a flow rate of 4-5 ml / min, and the percolation amount is 10 times the weight of the medicinal material. The extracts were combined, filtered and concentrated under reduced pressure. The concentrated solution was added with 4 times the amount of water to precipitate and then centrifuged. The precipitate was collected and dried under reduced pressure, crushed to obtain extract A, and the centrifuged supernatant was concentrated under reduced pressure for later use.

[0105] Take a medium-polar macroporous adsorption resin, pack it into a column at a ratio of 1:3 to the weight ratio of the crude drug, and then pass the above-mentioned concentrated solution for use through the macroporous resin column at a flow rate of 1 column volume / hour. After passing through completely, use Deionized water was used for elution, follow...

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Abstract

Cornus officinalis extract and its preparation method and use, including extracting the medicinal material of Cornus officinalis with ethanol, adding water to precipitate the extract after concentrating under reduced pressure, collecting the precipitate and drying under reduced pressure to obtain extract A; putting the supernatant on a macroporous adsorption resin column, and eluting with water Remove impurities, ethanol gradient elution, collect the eluent and dry under reduced pressure to obtain extract B; uniformly mix extract A and B to obtain the Cornus officinalis extract of the present invention, and its new medical use is in the preparation and prevention of diabetic vascular disease and Application of blood sugar lowering drugs.

Description

technical field [0001] The invention provides a cornus officinalis extract, and also relates to a preparation method of the extract and a medical application of the extract, belonging to the field of traditional Chinese medicines. Background technique [0002] Diabetes mellitus is a chronic systemic progressive endocrine and metabolic disease. Sustained high blood sugar can lead to abnormal metabolism of some tissues and organs, and then cause their dysfunction and morphological changes. The duration of diabetes is more than 10 years, and most patients are complicated with vascular complications of varying degrees, especially microvascular complications. Diabetic microangiopathy refers to microcirculatory disturbance, microangioma formation and thickening of microvascular basement membrane, mainly including diabetic nephropathy and diabetic retinopathy, which can lead to uremia or blindness in severe cases, causing great physical and mental pain to patients. Therefore, it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/40A61K131/00A61K31/7048A61P3/10A61P9/00C07H1/08C07H17/04
Inventor 肖伟潘扬丁岗章晨峰韩淑燕曹亮
Owner JIANGSU KANION PHARMA CO LTD
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