Chinese medicine composition for treating cardiac and cerebral vascular diseases and its prepn process

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of medicine and can solve problems such as the inability to obtain total salvianolic acid

Inactive Publication Date: 2006-12-27
深圳市健开医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Salvia miltiorrhiza is a traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis. A large number of studies have shown that the active ingredients of Danshen are total salvianolic acid, among which salvianolic acid B magnesium salt has the strongest effect, and the traditional water extraction method cannot obtain salvianolic acid. Total salvianolic acid with more acid B magnesium salt

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Get 10kg of Salvia miltiorrhiza, soak 30min with 70% acetone of 10 times the amount and start percolation, the percolation solution is concentrated under reduced pressure to no acetone smell, dilute the concentrated solution with an appropriate volume of water, according to the ratio of adsorption capacity 1: 1 (resin content and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 10 times the column volume of 20% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 40°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrated solution according to the following process: -50°C for 4 hours, -10°C for lyophilization, and warm to 20 ℃ of insulatio...

Embodiment 2

[0071] Get 10kg of Salvia miltiorrhiza, soak with 10 times the amount of 50% acetone for 30min and then start percolating. The percolating liquid is concentrated under reduced pressure until there is no acetone smell, dilute the concentrated solution with an appropriate volume of water, and use a ratio of 1:1 (resin content) and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 12 times the column volume of 30% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 45°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrate according to the following process: -50°C for 3 hours, -10°C for 3 hours, and heat up to Insulated at 20°C for 2 hours, then 318...

Embodiment 3

[0075] Take 1 kg of Danshen medicinal material, pulverize, dry, and pass through a 100-mesh sieve; take 0.2 kg of Acanthopanax medicinal material, pulverize, dry, and pass through a 60-mesh sieve. Mix the powders of the two medicinal materials evenly, put them into capsule shells, and make 5000 capsules.

[0076] group

[0077] Compared with the normal saline group: ** P*** P<0.01

[0078] group

[0079] Compared with the normal saline group: ** P*** P<0.01

[0080] group

[0081] Compared with the normal saline group: ** P*** P<0.01

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PUM

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Abstract

The Chinese medicine composition for treating cardiac and cerebral vascular diseases is prepared with red sage and manyprickle acanthopanax root or their extracted effective parts in certain proportion. The Chinese medicine composition may be prepared into different preparation forms for treating cerebral infarction, cerebral ischemia, coronary heart disease, andina pectoris, myocardial ischemia and other cardiac and cerebral vascular diseases, and is safe, effective, stable, controllable and convenient.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Parts or active ingredients are made into a composition according to a certain proportion. Background technique [0002] Danshen is a traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis. A large number of studies have shown that the active ingredient of Danshen is total salvianolic acid, among which salvianolic acid B magnesium salt has the strongest effect, and the traditional water extraction method cannot obtain salvianol-containing Acid B magnesium salt more total salvianolic acid. [0003] Acanthopanax is a variety recorded in the Chinese Pharmacopoeia. It is a small injection prepared from the medicinal materials of Acanthopanax senticosus. The ministerial standard stipulates that it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/254A61P9/10A61P9/06A61P9/04
Inventor 王俊雄
Owner 深圳市健开医药有限公司
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