Shallot extract as well as preparation method and usage thereof
A technology of extract, onion, applied in the field of medicine
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Embodiment 1
[0020] The preparation of embodiment 1 onion extract
[0021] After 10 kg of dried shallots are crushed, they are put into an extraction tank, boiled and extracted three times with 50 liters of pure water at 90-100°C, each extraction time is 1 hour, the three extractions are combined, concentrated to 20 liters, centrifuged, filtered, discarded To remove the precipitate, the supernatant was adjusted to 50 liters with distilled water. Slowly pass through an adsorption column equipped with 6 kg of polystyrene porous adsorption macroporous resin, rinse with 80 liters of distilled water to remove impurities; then elute with 50 liters of 50% aqueous ethanol, collect the eluate, concentrate to dryness, and further Dried and pulverized to obtain 0.09 kg of yellow powdered shallot extract, with a recall rate of 0.9% according to crude drug amount.
Embodiment 2
[0022] Therapeutic effect of embodiment 2 onion extracts on canine acute myocardial ischemia
[0023] In this experiment, anesthetized dogs were administered intragastrically with different doses of onion extract to observe its improvement and therapeutic effect on acute myocardial ischemia.
[0024] 1 Materials and methods
[0025] 1.1 Experimental animals
[0026] Healthy mongrel dogs (provided by the Animal Center of the Second Military Medical University, animal breeding certificate number: SCXK (Shanghai) 2002-0006; gender: both male and female; weight: 9-14kg; 5 dogs per group; total number of animals: 25 dogs)
[0027] 1.2 Administration method
[0028] Administration method: intragastric administration
[0029] Dosage: The low, medium and high doses of dogs are 15mg / kg (equivalent to 1.9g / kg of the original drug), 45mg / kg and 90mg / kg respectively; the positive control Xingling Granules is 300mg / kg (equivalent to ginkgo ketone ester 15mg / kg); normal saline is given ...
Embodiment 3
[0059] Example 3 Protective effect of Semen scallion extract on myocardial ischemia-reperfusion injury in rats
[0060] In this experiment, different doses of onion extract were given to rats by intragastric administration to observe its protective effect on myocardial ischemia-reperfusion injury in rats.
[0061] 1 Materials and methods
[0062] 1.1 Test animals
[0063] Sprague-Dawley rats (provided by the Animal Center of Shanghai Branch of the Chinese Academy of Sciences; animal certificate number: SCXK (Shanghai) 2002-0010; grade: clean grade, certificate number: Yidongzi No. 02-64; body weight: 250-300g ;Sex: female; 10 per group; total: 60)
[0064] 1.2 Administration method
[0065] Administration method: intragastric administration
[0066] Dosage: Low, medium and high doses for rats are 50mg / kg, 150mg / kg and 300mg / kg respectively. The dose of positive drug is 900mg / kg (equivalent to 45mg / kg of ginkgo ketone ester)
[0067] Dosing frequency: all single administr...
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