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European verbena herb extract, and preparing process and use thereof

A technology of verbena and extract, which is applied in the field of extracts and drugs for anti-early pregnancy and anti-trophoblastic tumors

Inactive Publication Date: 2003-10-29
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excavating the traditional Chinese medicine of the motherland, looking for an effective drug against trophoblast tumor, no report has been found in the literature search in the past 10 years

Method used

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  • European verbena herb extract, and preparing process and use thereof
  • European verbena herb extract, and preparing process and use thereof
  • European verbena herb extract, and preparing process and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1. The preparation of Verbena extract

[0046] Step 1: 10kg of whole Verbena herb is heated and extracted twice with 80kg of 95% ethanol, each time for 3 hours, cooled overnight, filtered to remove the precipitate, and the ethanol is recovered by distillation under reduced pressure (0.08MPa, 60°C) until there is no alcohol smell, Add water to make up to 2000ml (equivalent to 5g crude drug / mL),

[0047] Step 2, extract the aqueous solution obtained in step 1 with petroleum ether (60-90° C.) 4 times, each time using 1000 mL, keep the water layer,

[0048] Step 3, adding chloroform to the water layer retained in step 2 to extract 4 times, each time using 1000mL, distilling under reduced pressure (0.08MPa, 55°C), recovering chloroform until it is evaporated without solvent, and obtaining an extract, which is the horse whip of the present invention Grass extract, this verbena extract is equivalent to 100 grams of verbena crude medicine per milliliter.

Embodiment 2

[0049] Embodiment 2. Preparation of Verbena Extract

[0050] Step 1: Heat 10kg of whole verbena herb with 30kg of 95% ethanol to extract twice, each time for 3 hours, cool overnight, filter off the precipitate, and recover ethanol (0.09MPa, 70°C) by vacuum distillation until there is no alcohol smell , add water to 1500 ml (equivalent to 6.5g crude drug / mL),

[0051] Step 2, extract the aqueous solution obtained in step 1 with petroleum ether (60-90° C.) for 3 times, each time using 1500 mL, keep the water layer,

[0052] Step 3: add the water layer retained in step 2 to extract 4 times with chloroform, use 1500mL each time, distill under reduced pressure (0.09MPa, 65°C), recycle the chloroform until it is evaporated without solvent, and obtain the extract, which is the horsewhip of the present invention Grass extract, this verbena extract is equivalent to 100 grams of verbena crude medicine per milliliter.

Embodiment 3

[0053] Embodiment 3. Preparation of Verbena Extract

[0054] Step 1: 10kg of whole Verbena herb, heat and extract twice with 50kg of 95% ethanol, each time for 3 hours, cool overnight, filter off the precipitate, distill under reduced pressure (0.09MPa, 70°C), reclaim ethanol until there is no alcohol taste, add water to 3000 ml (equivalent to 3.3g crude drug / mL),

[0055] Step 2, extract the aqueous solution obtained in step 1 with petroleum ether (60-90° C.) for 3 times, each time using 3000 mL, keep the water layer,

[0056] Step 3, add the water layer retained in step 2 to extract 4 times with chloroform, use 3000mL each time, distill under reduced pressure (0.09MPa, 65°C), recycle the chloroform until it is evaporated without solvent, and obtain the extract, which is the horsewhip of the present invention Grass extract, this verbena extract is equivalent to 100 grams of verbena crude medicine per milliliter.

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Abstract

An extract of verbena herb is prepared from the verbena herb through extracting in alcohol, concentrating, adding water, extracting with petroleum ether, extracting with chloroform, and distilling. It can be used to prepare the medicines for resisting early pregnancy and treating the tumor of trophocyte.

Description

1. Technical field [0001] The invention relates to extracts of verbena and anti-early pregnancy and anti-trophoblast tumor drugs. 2. Background technology [0002] Verbena is a plant of the Verbena family Verbenaceae (Verbenaceae), scientific name Verbena officinalis, is a traditional Chinese medicine. According to "Compendium of Materia Medica", its seedlings and leaves can be used to clear away heat and detoxify, diuretic and reduce swelling, and the Chinese Pharmacopoeia records it as clearing away heat, cooling blood, breaking blood and reducing swelling. [0003] Family planning is a national policy of our country. Since there is no perfect contraceptive measure at present, artificial abortion is an indispensable remedy for contraceptive failure. According to statistics, about 14 million people in my country undergo artificial abortion every year. Although abortion is relatively safe and simple, it still has certain complications and causes mechanical damage to the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P15/04A61P35/00C07H1/08C07H17/04
Inventor 徐昌芬曾群徐珊罗莉
Owner NANJING MEDICAL UNIV
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