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COmpound Bajisu A and its prepn and use

A technology of Morindatin and compounds, which is applied in the fields of medicine and health, food and chemical industry, and can solve problems such as discovering new compounds

Inactive Publication Date: 2004-04-07
林翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the composition of Morinda officinalis in foreign countries; a series of research on the composition of Morinda officinalis has been carried out in China for a long time, and it is found that Morinda officinalis contains anthraquinones, iridoids, volatile components, organic acids, amino acids , trace elements, β-sitosterol and other components, and it was also found that Morinda officinalis contains known oligosaccharide sugars such as Nessose; however, so far, no new compound has been found from Morinda officinalis

Method used

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  • COmpound Bajisu A and its prepn and use
  • COmpound Bajisu A and its prepn and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 500 grams of the fleshy root of Morinda officinalis, remove the wooden core, chop it, and decoct it with 1500 ml of water for 1 hour, filter it, and decoct the medicinal residue with 500 ml of water for another 1 hour, filter it, combine the filtrates, concentrate under reduced pressure to about 100 ml, and move to a large In the Erlenmeyer flask, after cooling, add ethanol until the alcohol content is 65%, airtightly place it at 8°C and let it stand still to precipitate a precipitate. After standing for 3 days, pour out the supernatant to obtain a brown-gray precipitate. Take the Buchner funnel with filter paper installed in the sedimentation device, wash it repeatedly with ethanol, drain it, take out the precipitate, dissolve it with a small amount of water, put it on the DA101 macroporous resin column in the usual way, wash it with water, and receive it in 50ml per part, of which 3-8 parts The receiving solution was concentrated under reduced pressure to 30ml, an...

Embodiment 2

[0024] Take 500 grams of the fleshy roots of Morinda officinalis, remove the wooden core and chop, reflux with 1000ml of 60% ethanol for 1 hour, filter, decoct the dregs with 500ml of 60% ethanol for another 1 hour, filter, combine the filtrates, and concentrate under reduced pressure to about 100ml, moved to a large Erlenmeyer flask, after cooling, add ethanol until the alcohol content is 65%, airtightly place it at 8°C and let it stand to precipitate a precipitate. After standing for 3 days, pour out the supernatant to obtain a brownish gray precipitate. Take the Buchner funnel with filter paper installed in the sedimentation device, wash it repeatedly with ethanol, drain it, take out the precipitate, dissolve it with a small amount of water, put it on the DA101 macroporous resin column in the usual way, wash it with water, and receive it in 50ml per part, of which 3-8 parts The receiving solution was concentrated under reduced pressure to 30ml, and then ethanol was added unt...

Embodiment 3

[0026] Take 500 grams of the fleshy roots of Morinda officinalis, remove the wooden core and chop, then reflux with 1500ml of 60% ethanol for 1.5 hours, filter, decoct the dregs with 700ml of 60% ethanol for another 1 hour, filter, combine the filtrates, and concentrate under reduced pressure to about 100ml, moved to a large Erlenmeyer flask, after cooling, add ethanol until the alcohol content is 65%, airtightly place it at 8°C and let it stand to precipitate a precipitate. After standing for 3 days, pour out the supernatant to obtain a brownish gray precipitate. Take the Buchner funnel with filter paper installed in the sedimentation device, wash it repeatedly with ethanol, drain it, take out the precipitate, dissolve it with a small amount of water, put it on the DA101 macroporous resin column in the usual way, wash it with water, and receive it in 50ml per part, of which 3-8 parts Concentrate the receiving solution to 30ml under reduced pressure, then add ethanol until the ...

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PUM

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Abstract

The present invention relates to medicinal and food chemical industry, and is Baijisu A as one new compound and its preparation and use. The fleshy root traditional kindney invigorating Chinese medicine morinda root has, modern research shows, corticotropic hormone-like effect, function of strengthening thalamous-pitutary-sex gland axis, function of strengthening thyroid gland, promoting breeding and other kidney invigorating functions. The preparation process of Bajisu A includes extraction with solvent, concentration, alcohol precipitation, column chromatographic separation and re-crystallization. Compound Bajisu A may be used in preventing and treating senile dementia and other senile diseases as well as teenage's hypophrenosis, and may be used as food additive, health food, etc.

Description

technical field [0001] The invention belongs to the industries of medicine and sanitation and food chemical industry. Mainly the new compound Morinda officinalis and its preparation method and application. Background technique [0002] Morinda officinalis How, a traditional Chinese medicine, is the fleshy root of Morinda officinalis How, a plant of the Rubiaceae family. It is widely planted in Guangdong and Jiangnan provinces. It has been a traditional Chinese medicine for tonifying the kidney since ancient times. Modern studies have confirmed that Morinda officinalis has adrenocorticotropic hormone-like effects, enhances the function of the hypothalamus-pituitary-gonad axis, enhances thyroid function, promotes fertility, promotes corticosterone secretion, and improves the sexual vitality and eclosion rate of fruit flies. There is no report on the composition of Morinda officinalis in foreign countries; a series of research on the composition of Morinda officinalis has been...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L33/125A61K31/7016A61P25/28A61P43/00C07H1/08C07H3/04
Inventor 林励
Owner 林翔
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