Trimebutine maleate tablet and preparing method thereof

Abstract

The present invention relates to a kind of oral trimebutine tablet and its preparation method. Said invention is characterized by that the trimebutine raw material can be coated with water soluble film-forming agent and plasticizer. The tablet made up by said method can hide the taste of trimebutine, at the same time it does not affect disintegration and does not affect resolution of its main component.

Description

technical field

[0001] The invention relates to a trimebutine maleate tablet for oral administration and a preparation method thereof. Background technique

[0002] Because trimebutine maleate has a persistent and unbearable astringent taste, if you take a conventional tablet orally, a strong numb taste will be produced when the medicine comes into contact with the tongue, making it impossible for people to continue taking it.

[0003] Previously known technologies only relate to the persistent bitter taste of trimebutine maleate or to ensure the stability of trimebutine maleate during preparation and storage of medicines, but are not perfect.

[0004] FR2468364, published May 8, 1981, describes a process for the preparation of microcapsules filled with pharmaceutically active compounds, the walls of which are ethylcellulose, carried out in cyclohexane, using phase separation An inducer, preferably a phospholipid phase separation inducer, as an example, trimebutine maleate ...