Composition for blood serum or plasma separation and vessel for blood examination containing the same

A technology of composition and serum, which is applied in the field of compositions for separating serum or plasma, and can solve problems such as poor compatibility

Inactive Publication Date: 2004-09-29
SEKISUI CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition contains components that are poorly compatible with each other

Method used

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  • Composition for blood serum or plasma separation and vessel for blood examination containing the same
  • Composition for blood serum or plasma separation and vessel for blood examination containing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-12

[0088] (Preparation of isolate composition and blood collection tube)

[0089] Didecyl phthalate as the phthalate, polycyclic hydrocarbon compounds listed in Table 1, and dibenzylidene sorbitol (DBS) as the organogelling agent were charged into a 2-liter glass beaker, It was then heated at 130°C to make a solution. Additional cyclopentadienyl oligomer was added and then heated to bring the contents of the beaker into solution. The preparation of each solution is shown in Table 2

[0090] Silica fine particles were added to each solution at 35°C or lower. The resulting mass was kneaded in a planetary mixer to obtain an isolate composition having a specific gravity of 1.04-1.06.

[0091] Each isolate composition was filled into 20 hard glass test tubes with a volume of 10 ml, and 1.5 g was added to each tube to prepare blood collection tubes.

[0092] (performance evaluation)

[0093] 10 of the 20 blood collection tubes were stored at room temperature for one week. The rem...

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Abstract

A composition for blood serum or plasma separation which has improved compatibility between a cyclopentadiene oligomer and a phthalic ester and generates no oily ingredient suspending in the blood serum or plasma after centrifugal separation regardless of the conditions for the centrifugal separation; and a vessel for blood examination which contains the composition. The composition for blood serum or plasma separation comprises: a polycyclic hydrocarbon compound having an unsaturated and / or saturated cyclic structure in the molecule and having a solidifying point or pour point of 0 DEG C or lower; a cyclopentadiene oligomer; and a phthalic ester.

Description

technical field [0001] The present invention relates to a composition for separating serum or plasma by utilizing the difference in specific gravity between blood components, and to a blood testing container containing the composition. Background technique [0002] Japanese Patent Publication No. Sho 51-83654 discloses a blood test container in which a thixotropic serum or plasma separator composition, eg, a mixture of silicone and silicon dioxide, is already contained at the bottom of a blood collection tube. Blood is collected in blood collection tubes, allowed to stand for an appropriate time and centrifuged. The colloidal serum or plasma isolate composition then becomes flowable under the action of centrifugal force. Meanwhile, the specific gravity of the colloidal serum or plasma isolate composition is between (1.03-1.07) between serum or plasma components (specific gravity about 1.02) and blood clot or cell components (specific gravity about 1.08). Thus, the isolate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/14G01N33/50
CPCB01L3/50215B01L2300/12G01N33/5002G01N33/48
Inventor 安乐秀雄冈本隆介
Owner SEKISUI CHEM CO LTD
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