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New use of sulpirde in pharmacy

A technology of dioxymethamphetamine and neurotoxicity, applied in the field of pharmaceuticals, to achieve the effect of resisting harm, obvious social benefit and economic benefit

Inactive Publication Date: 2005-02-16
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

At present, the main treatment and intervention directions focus on using drugs to induce hypothermia or prevent MDMA-induced hyperthermia, but there is no drug that can effectively antagonize this type of neurotoxicity

Method used

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  • New use of sulpirde in pharmacy
  • New use of sulpirde in pharmacy
  • New use of sulpirde in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] 1. Materials and methods

[0016] 1.1 Materials

[0017] 1.1.1 Animals 150 male Wistar rats, weighing 140±2 grams, were purchased from the Experimental Animal Center of Sichuan University. The animals were randomly divided into 10 groups, 15 in each group. Before the experiment, the animals were allowed to adapt to a clean constant temperature (20°C ± 2°C) constant humidity (humidity 50%) breeding room for 3 days, grabbed once a day, and raised in a single cage. During the whole experiment, they were allowed to drink water and eat freely.

[0018] 1.1.2 Drugs and reagents MDMA is provided by the China Institute for the Control of Pharmaceutical and Biological Products. Sulpiride was provided by Shanghai Hefeng Pharmaceutical Factory (batch number 000801). All the above medicines were dissolved in normal saline, and the administration volume was 1ml / kg. SERTmRNA in situ hybridization kit was purchased from Wuhan Boster Company. 10% chloral hydrate (provided by the Ph...

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Abstract

The invention discloses the application of sulpiride in curing or preventing neurotoxicity caused by 3,4 methylene dioxygen methyl Benzedrine (MDMA). It feeds sulpiride to write rat before feeding MDMA, feeds sulpiride to experiment write rat when feeding MDMA to it, and feeds sulpiride to write rat half hours, five hours and twelve hours after feeding MDMA to it, it can reduce the exaust of brain areas 5-HT of frontal lobe cortex, hippocampal sulcus and corpus striatum, and has prominent resisting effect to the lessen of SERTmRNA representation; the result of neuropathology displays: the sulpiride also can resist the reduction of silver staining positive area caused by MDMA, and lessens the representation of gelatinous fiber acid protein (GFAP), this reflects the lessen of damage to the nerve. The dose of the sulpiride is 40mg / kg-80mg / kg.

Description

technical field [0001] The present invention relates to the use of the antipsychotic drug sulpiride, especially the use in the field of pharmacy. Background technique [0002] 3,4-methylenedioxy-methamphetamine (3,4-methylenedioxy-methamphetamine, MDMA, commonly known as "ecstasy" in my country, in the follow-up content of this manual, "MDMA" stands for "3,4-methylenedioxymethyl Amphetamine") belongs to the amphetamine-type stimulants and is also a powerful indirect monoaminergic agonist that can induce novelty, enhance pleasure, and increase excitability. It is an illegal drug that is easily obtained in entertainment venues (Kaplan HI, and Sadock BJ. Synopsis of Psychiatry. 8th ed. Baltimore: Maryland Composition publishers, Inc. 1998, pp: 407-412). In recent years, amphetamine-type stimulants represented by MDMA have spread rapidly internationally, and our country is also facing the threat of MDMA epidemic abuse after heroin. MDMA can destroy the...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61P25/00A61P25/36
Inventor 王雪黄明生孙学礼李静李素霞况伟宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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