Compound baking soda injection and its preparation

A compound sodium bicarbonate, sodium bicarbonate technology, applied in pharmaceutical formulations, aluminum/calcium/magnesium active ingredients, drug delivery, etc. PH value etc.

Inactive Publication Date: 2005-03-16
李玉才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem with trisaminomethane is that it causes the patient to stop breathing after intravenous injection, and the patient often needs urgent intubation
However, because it cannot effectively increase the pH value of the cells and cannot effectively correct the acidosis in the cells, it still has no effective therapeutic effect in patients treated by clinical cardiopulmonary cerebral resuscitation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Compound sodium bicarbonate injection of the present invention is made up of following components by weight ratio:

[0021] Sodium bicarbonate: Trisaminomethane = 1:2

[0022] The preparation method of the present invention comprises the following steps:

[0023] (1) Get 200kg of tris(hydroxymethyl)aminomethane (THAM) powder according to the above weight ratio, add distilled water accounting for 75% of the total solution, and obtain a completely dissolved trisaminomethane solution for use;

[0024] (2) Get a trace amount of hydrochloric acid to titrate the pH value of the completely dissolved trisaminomethane solution to 8.2;

[0025] (3) get sodium bicarbonate (NAHCO3) powder 100kg by above-mentioned weight ratio, add and account for the distilled water of 18% of total solution, must dissolve sodium bicarbonate solution completely and stand-by;

[0026] (4) Mix the completely dissolved sodium bicarbonate solution into the trisaminomethane solution whose pH is 8.2.

...

Embodiment 2

[0030] Compound sodium bicarbonate injection of the present invention is made up of following components by weight ratio:

[0031] Sodium bicarbonate: Trisaminomethane = 1:3

[0032] The preparation method of the present invention comprises the following steps:

[0033] (1) get trisaminomethane powder 300kg by above-mentioned weight ratio, add and account for 75% distilled water of total solution, obtain the trisaminomethane solution of dissolving completely and stand-by;

[0034] (2) Get a trace amount of hydrochloric acid to titrate the pH value of the completely dissolved trisaminomethane solution to 9.0;

[0035] (3) get sodium bicarbonate powder 100kg by above-mentioned weight ratio, add and account for the distilled water of 18% of total solution, must dissolve completely sodium bicarbonate solution stand-by;

[0036] (4) Mix the completely dissolved sodium bicarbonate solution into the trisaminomethane solution whose pH is 9.0.

[0037] (5) Add the total amount of th...

Embodiment 3

[0040] Compound sodium bicarbonate injection of the present invention is made up of following components by weight ratio:

[0041] Sodium bicarbonate: Trisaminomethane = 1: 2.5

[0042] The preparation method of the present invention comprises the following steps:

[0043] (1) get trisaminomethane powder 250kg by above-mentioned weight ratio, add and account for 75% distilled water of total solution, obtain the trisaminomethane solution of dissolving completely and stand-by;

[0044] (2) Get a trace amount of hydrochloric acid to titrate the pH value of the completely dissolved trisaminomethane solution to 8.6;

[0045] (3) get sodium bicarbonate powder 100kg by above-mentioned weight ratio, add and account for the distilled water of 18% of total solution, must dissolve completely sodium bicarbonate solution stand-by;

[0046] (4) Mix the completely dissolved sodium bicarbonate solution into the trisaminomethane solution whose pH is 8.6.

[0047] (5) Add the total amount of...

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PUM

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Abstract

The invention provides a compound sodium bicarbonate injection for treating body acid and alkali metabolic disorder caused by various diseases. The injection comprises the followingraw materials (by weight ratio), sodium bicarbonate : Aamresco. Tris Base = 1 : (2-3).

Description

technical field [0001] The invention relates to a compound sodium bicarbonate injection and a preparation method thereof, which belongs to an alkaline buffer solution and is a medicine for clinically treating various diseases that cause or eventually lead to acid-base metabolism disorders (metabolic acidosis) in a body. Alkaline buffer solution is an extremely important therapeutic drug in various acute and severe rescues, various severe shocks, clinical multiple organ failure, organ transplantation, major cardiovascular surgery, especially in cardiopulmonary cerebral resuscitation. Background technique [0002] In the 1950s, alkaline buffer sodium bicarbonate (NAHCO3) began to be used clinically. Tris(hydroxymethyl)aminomethane (THAM) appeared clinically in the 1960s. Due to the serious side effects of these drugs, the clinical application of these drugs is limited. After intravenous injection of sodium bicarbonate, the patient's arterial blood carbon dioxide partial pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/10A61P3/00
Inventor 李玉才
Owner 李玉才
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