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Compound light-yellow sophora root freeze-drying injection and preparation thereof

A technology of compound Sophora flavescens and Sophora flavescens, which is applied in the direction of freeze-drying transportation, powder transportation, medical formula, etc., can solve the problem of no report of compound flavescens freeze-dried powder injection, and achieve long-term storage, reduce dosage, and high purity Effect

Inactive Publication Date: 2005-10-12
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report of compound Sophora flavescens freeze-dried powder injection in the data retrieval

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] (1) Take 1200g of Sophora flavescens and crush it, pass through a 20-mesh sieve, pack it into the percolation cylinder after wetting and swelling with 0.1% hydrochloric acid solution, add 0.1% hydrochloric acid to soak for 4 hours, connect the percolation cylinder with strong acidic cation exchange resin, and carry out Percolation, the percolation liquid is passed through the resin column, and the exchanged resin is eluted with ammonia alcohol added to ethanol to a pH value of 9-10, and the ethanol is recovered from the ammonia alcohol eluate and concentrated to obtain a concentrated solution 1. Add 600g of Sophora flavescens and Baituling to decoct twice, 1 hour each time, combine the decoction, concentrate to 1.5g crude drug / ml; add ethanol to make the alcohol content reach 65%, let it stand, filter, and decompress Recover ethanol and concentrate to 2 g crude drug / ml, add ethanol to make the alcohol content 90%, let it stand, filter, recover ethanol under reduced press...

Embodiment 2

[0071] (1) Take 1200g of Sophora flavescens and grind it through a 40-mesh sieve. After wetting and swelling with 1% acetic acid solution, put it into the percolation cylinder, add 1% acetic acid to soak for 4 hours, connect the percolation cylinder with strong acidic cation exchange resin, and carry out Percolation, the percolation liquid is passed through the resin column, and the exchanged resin is eluted with ammonia alcohol added to ethanol to a pH value of 9-10, and the ethanol is recovered from the ammonia alcohol eluate and concentrated to obtain a concentrated solution 1. Add 600g of Sophora flavescens and Baituling to decoct twice, 2 hours each time, combine the decoction, concentrate to 1.5g crude drug / ml; add ethanol to make the alcohol content reach 65%, let stand, filter, decompress Recover ethanol and concentrate to 2 g crude drug / ml, add ethanol to make the alcohol content 90%, let it stand, filter, recover ethanol under reduced pressure, and obtain concentrated...

Embodiment 3

[0076] (1) Take 1200g of Sophora flavescens, pass through a 30-mesh sieve, pack it into the percolation cylinder after wetting and swelling with 0.1% hydrochloric acid solution, add 0.1% hydrochloric acid to soak for 4 hours, connect the percolation cylinder with strong acidic cation exchange resin, and carry out Percolation, the percolation liquid is passed through the resin column, and the exchanged resin is eluted with ammonia alcohol added to ethanol to a pH value of 9-10, and the ethanol is recovered from the ammonia alcohol eluate and concentrated to obtain a concentrated solution 1. Add 600g of Sophora flavescens and Baituling to decoct twice, 3 hours each time, combine the decoction, concentrate to 1.5g crude drug / ml; add ethanol to make the alcohol content reach 65%, let it stand, filter, and decompress Recover ethanol and concentrate to 2 g crude drug / ml, add ethanol to make the alcohol content 90%, let it stand, filter, recover ethanol under reduced pressure, and obt...

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PUM

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Abstract

A Chinese medicine in the form of powder injection is prepared from flavescent sophora root and white China root through extracting, purifying, mixing with additive and freeze drying.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a compound flavescens freeze-dried powder injection and a preparation method thereof. technical background [0002] Compound Matrine Injection is composed of Sophora flavescens and Baituling. The main chemical components of the injection are oxymatrine, matrine, sophocarpine, matrine flavonoids, and saponins. It has the functions of clearing away heat and promoting dampness, cooling blood and detoxifying, dispelling stagnation and relieving pain. Compound Kushen Injection has the functions of stopping bleeding, relieving pain, and inhibiting the proliferation of cancer cells. At the same time, it can also improve hematopoietic function and increase the body's immunity. It provides a reliable means for the rehabilitation of cancer patients and effectively improves the quality of life of patients. The development of this drug broke the his...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P7/06A61P35/00
Inventor 张海峰
Owner 张海峰
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