Technique for preparing oral taking fluid mixed with boiling water of gentamicin sulphate

Abstract

An orally-taken infusion of gentamycin sulfate is prepared through mixing cyclodextrin with gentamycin sulfate, mixing with xylitol or pectose, granulating, and coating the particles by sodium thiosulfate (or sulfite).

Description

technical field [0001] The invention relates to a medicine preparation method, in particular to a preparation process of gentamicin sulfate oral granules. Background technique [0002] Gentamicin Sulfate Oral Granules (Pediatric Libao) is a commonly used drug for children. For the convenience of children, gentamicin sulfate is mixed with flavoring agent sucrose to make granular granules. It is clinically found that the drug degrades seriously. Generally, within two months after leaving the factory, the active ingredients are degraded by 20%-50%. Contents of the invention [0003] The present invention aims at the serious degradation defect of existing gentamicin sulfate oral granules, and proposes a preparation process of gentamicin sulfate oral granules. The process is to mix gentamicin sulfate and flavoring agent to make granules. The cyclodextrin and gentamycin are first mixed to make the cyclodextrin molecule include...

AI Technical Summary

Problems solved by technology

It is clinically found that the drug degrades seriously. Generally, within two months after leaving the factory, the active ingredients degrade by 20%-50%. Some products even fail to pass the factory, which seriously affects the efficacy of the drug.