Methods of increasing platelet and hematopoietic stem cell production

A technology of hematopoietic stem cells and stem cells, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, peptide/protein components, etc., which can solve problems such as increasing mortality, increasing health care costs, and reducing the quality of life of subjects
CN1723036AInactive Publication Date: 2006-01-18ORTHO MCNEIL PHARM INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ORTHO MCNEIL PHARM INC
Publication Date
2006-01-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for increasing the production of hematopoietic stem cells. The method includes administering a TPO mimetic compound to a subject. The invention also discloses a pharmaceutical composition comprising a TPO mimetic compound and a pharmaceutically acceptable carrier.
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Description

[0001] This application claims priority to Serial Nos. 60 / 411,779 and 60 / 411,700, filed September 18,2002. Background of the invention

[0002] Thrombopoietin (TPO), originally cloned as a master regulator of platelet production, has a pivotal role in hematopoietic stem cell (HSC) biology. Kaushansky et al., Nature, 369:568-571 (1994). Virtually all primitive HSCs with repopulation activity expressed the receptor for c-Mpl-TPO. Solar et al., Blood, 92:4-10 (1998). TPO alone or in combination with other early acting cytokines such as stem cell factor (SCF), interleukin 3 (IL-3) or Flt-3 ligand enhances the in vitro proliferation of naive HSCs. Ku et al., Blood, 87:4544-4551 (1996); Sitnicka et al., Blood, 87:4998-5005 (1996). In vivo experiments confirmed these conclusions. Kimura et al., Proc. Natl. Acad. Sci. U.S.A., 95: 1195-1200 (1998). The importance of TPO self-renewal and expansion in stem cells is also supported by clinical observations of c-Mpl gene mutations in c...

Claims

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