Extractive from Gypsophila oldhamiana Miq with anti-cancer activity, prepn. method and application therewith

An extraction method and extract technology are applied in the field of preparation of the medicinal extract, and can solve the problems of unreported chemical components and pharmacological effects, few research on plants, etc.

Inactive Publication Date: 2006-01-25
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are few domestic studies on this plant, and no studies on chemical constituents and pharmacological effects have been reported.

Method used

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  • Extractive from Gypsophila oldhamiana Miq with anti-cancer activity, prepn. method and application therewith
  • Extractive from Gypsophila oldhamiana Miq with anti-cancer activity, prepn. method and application therewith
  • Extractive from Gypsophila oldhamiana Miq with anti-cancer activity, prepn. method and application therewith

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Take 10kg of rosagrass, add 90kg of water, boil and extract for 3 hours, filter, and the filtrate is set aside, add 90kg of water to the dregs, boil and extract for 3 hours, filter, combine the two filtrates, concentrate and spray dry the combined filtrate to obtain saponin 5 % Xiacao extract, to obtain a saponin content of 5% Chinese medicine extract with anticancer activity and antiviral activity. Add water to this extract to form a dilute extract with a relative density of 1.09, pass the dilute extract through a macroporous adsorption resin, wash with water until it is colorless, discard the water eluent, and then elute with 40% methanol to Colorless, collect this 40% ethanol eluate, concentrate the eluate after reclaiming ethanol into a thick extract with a relative density of 1.16, and spray dry this thick extract to obtain a saponin-containing 30% Herba Grass extract, namely A traditional Chinese medicine extract with anticancer activity and antiviral activity wit...

Embodiment 2

[0114] Take 10kg of Xiacao, add 80kg of water, boil and extract for 2 hours, filter, and the filtrate is set aside, add 90kg of water to the dregs, boil and extract for 4 hours, filter, combine the two filtrates, and concentrate the combined filtrate into a dilute leaching solution with a relative density of 1.26 Add ethanol to the ethanol content of 40%, let it stand for 16 hours, take the supernatant, recycle the ethanol from the supernatant, and form an extract with a relative density of 1.12, pass the thin extract through the macroporous adsorption resin, and use Wash with water until it is colorless, discard the water eluate, then elute with 85% ethanol until it is colorless, collect the 85% ethanol eluate, concentrate the eluate after recovering ethanol into a thick immersion solution with a relative density of 1.16 Paste, the thick extract is spray-dried to obtain a saponin-containing 50% rosa japonica extract, namely a traditional Chinese medicine extract with a saponin...

Embodiment 3

[0116] Take 10kg of Xiacao, add 100kg of water, boil and extract for 8 hours, filter, and the filtrate is set aside, add 80kg of water to the dregs, boil and extract for 8 hours, filter, combine the two filtrates, and concentrate the combined filtrate into a dilute extract with a relative density of 1.06 paste, add ethanol to ethanol content of 95%, let it stand for 24 hours, take the supernatant, recycle the ethanol from the supernatant, and form an extract with a relative density of 1.05, pass this thin extract through the macroporous adsorption resin, and use Wash with 10% ethanol until colorless, discard the ethanol eluate, then elute with 50% ethanol until colorless, collect the 50% ethanol eluate, concentrate the eluate after recovering ethanol to a relative density of 1.20 The thick extract, the thick extract is dried under reduced pressure to obtain the Herba Grass extract containing 70% saponin, that is, the Chinese medicine extract with anticancer activity and antivir...

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PUM

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Abstract

An anticancer substance used to preparing the anticancer medicines and antiviral medicines is extracted from Gypsophila old hamiana. Its advantages are high content of saponin (100%) after refining, high effect and low by-effect.

Description

Technical field: [0001] The present invention relates to a traditional Chinese medicine extract, more specifically, the present invention relates to an effective part extracted from the root of Gypsophila oldhamiana Miq., a plant of the genus Gypsophila in the caryophyllaceae family, and the present invention also relates to the preparation of the medicinal extract method and its application. Background technique: [0002] With the advancement of medicine, malignant tumor---cancer has become one of the main diseases that are common and seriously threaten human life and quality of life. At present, traditional Chinese medicine is divided into two categories when used for tumor treatment, one is therapeutic medicine, such as certain Compound prescriptions, but there are disadvantages such as unknown ingredients, unclear mechanism, and low potency. Some compound prescriptions even contain highly toxic ingredients, which are prone to serious toxic and side effects; , chemothera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61P35/00
Inventor 仲英左春旭刘鲁王元书孙敬勇谢砚英王菊
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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