Nanometer manetic powder for magnetothermical therapy and anti-CEA antibody target medicine

Abstract

The present invention relates to target medicine of nanometer magnetic powder and anti-CEA antibody for magentothermical therapy on colon cancer, stomach cancer, liver cancer, etc. The present invention features that nanometer magnetic powder and antibody in the weight ratio of 1 to 0.0001-0.20 are coupled via mixing in solution to prepare the nanometer target medicine. The target medicine has grain size one 5-1000 nm, nanometer magnetic powder with one or several antibodies coupled to the surface, and bioactivity. The target medicine is injection with medicine dispersed into nanometer grains, and is targeted and concentrated to the cancer focus. Under the action of the AC magnetic field of the magentothermical therapy instrument, the target medicine produces hysteresis heat effect of 10-7000 W / gFe to heat the cancer focus to 42-95 deg.c and kill cancer cell. The target medicine has biodegrading function and is used in the magentothermical treatment of cancer without toxic side effect.

Description

technical field

[0001] The invention relates to a nanometer magnetic powder-anti-CEA antibody targeted drug for magnetic hyperthermia therapy of cancers such as colon cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer and breast cancer. Background technique

[0002] Cancer is one of the most harmful diseases to human health. There are approximately 2.2 to 2.5 million new cancer patients in my country every year, and the death toll ranks first and second among the causes of death among urban and rural residents, respectively. Experts predict that the number of malignant tumor patients in my country will double in the next 20 years, and mankind is facing new challenges in the prevention and treatment of cancer. At present, lung cancer, liver cancer, gastric cancer, esophageal cancer, colorectal cancer, breast cancer, cervical cancer and nasopharyngeal cancer in my country account for more than 80% of cancer deaths, which are the focus of cancer prevention an...