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Nanometer manetic powder for magnetothermical therapy and anti-CEA antibody target medicine

A nano-magnetic powder, antibody targeting technology, applied in the direction of antibodies, drug combinations, anti-tumor drugs, etc., to achieve long-term circulation stability, good targeting function, and good penetration.

Inactive Publication Date: 2006-05-17
南京伍盛纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, magnetic thermal seeds in magnetic hyperthermia still need to be introduced into tumor lesions by means of implantation, local injection, mediation, etc., and it has not been seen that nano magnetic powders and antibodies are coupled to make magnetic thermal seeds for magnetic hyperthermia (ie, nano Bibliographical reports of targeted drugs actively targeted into tumor lesions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The particle size distribution range is 1-5nm, about 10nm and 10-40nm, 30-50nm, 50-100nm, 100-150nm and 950nm, and the surface is modified by sodium oleate, n-decanoic acid, polyethylene glycol, etc. Modified or respectively by dextran, liposome, nano-SiO 2 The weight ratios of superparamagnetic and ferrimagnetic nano-magnetic powders and anti-CEA antibodies that are coated or not surface modified and coated are 1:0.2, 1:0.1 and 1:0.1, 1:0, respectively. 0.05, 1:0.001, 1:0.0001 were mixed and coupled in aqueous solution to prepare nano magnetic powder-anti-CEA antibody targeting drug. The Zetasizer3000 laser particle size analyzer was used to measure the particle size of targeted drugs prepared from nano-magnetic powders with particle size distribution ranges of 1-5nm, about 10nm and 10-40nm, 30-50nm, 50-100nm, 100-150nm and 950nm The distribution ranges are 15-20nm, about 20nm and 20-70nm, 40-80nm, 60-130nm, 110-180nm and 960-1000nm respectively. The feeding ratio is...

Embodiment 2

[0024] The JEM-2010 UHR high-resolution transmission electron microscope analysis shows that the particle size of the targeted drug formed by coupling the superparamagnetic nano-magnetic powder with a particle size of about 10 nm and the anti-CEA antibody in the above-mentioned Example 1 is about 20 nm. The nano-magnetic powder and the antibody form a good coupling, and the surface of the nano-magnetic powder of the drug is coupled with an anti-CEA antibody.

Embodiment 3

[0026] (1) After mixing the nano-magnetic powder with the weight ratio of raw materials of 1:0.005 and sodium oleate in water, the nano-magnetic powder with the weight ratio of raw materials of 1:0.005 and sodium lauryl sulfate is mixed in water to make nano-magnetic powder. 2 modifications Modified functionalized surface. (2) After mixing the nano-magnetic powder with the weight ratio of the raw material of 1:0.01 and polyethylene glycol in water, and then mixing the nano-magnetic powder with the silicon dioxide nano-particle in the water with the raw material weight ratio of 1:1.5 to make the nano-magnetic powder. 1 modified and 1 encapsulated functionalized surface. (3) After mixing nano-magnetic powder and polyethylene glycol in water with a raw material weight ratio of 1:0.01, the liposome solution dissolved in ethanol is mixed with polyethylene glycol-modified nano-magnetic powder in water to prepare a The functionalized surface of secondary modification and primary coa...

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PUM

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Abstract

The present invention relates to target medicine of nanometer magnetic powder and anti-CEA antibody for magentothermical therapy on colon cancer, stomach cancer, liver cancer, etc. The present invention features that nanometer magnetic powder and antibody in the weight ratio of 1 to 0.0001-0.20 are coupled via mixing in solution to prepare the nanometer target medicine. The target medicine has grain size one 5-1000 nm, nanometer magnetic powder with one or several antibodies coupled to the surface, and bioactivity. The target medicine is injection with medicine dispersed into nanometer grains, and is targeted and concentrated to the cancer focus. Under the action of the AC magnetic field of the magentothermical therapy instrument, the target medicine produces hysteresis heat effect of 10-7000 W / gFe to heat the cancer focus to 42-95 deg.c and kill cancer cell. The target medicine has biodegrading function and is used in the magentothermical treatment of cancer without toxic side effect.

Description

technical field [0001] The invention relates to a nanometer magnetic powder-anti-CEA antibody targeted drug for magnetic hyperthermia therapy of cancers such as colon cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer and breast cancer. Background technique [0002] Cancer is one of the most harmful diseases to human health. There are approximately 2.2 to 2.5 million new cancer patients in my country every year, and the death toll ranks first and second among the causes of death among urban and rural residents, respectively. Experts predict that the number of malignant tumor patients in my country will double in the next 20 years, and mankind is facing new challenges in the prevention and treatment of cancer. At present, lung cancer, liver cancer, gastric cancer, esophageal cancer, colorectal cancer, breast cancer, cervical cancer and nasopharyngeal cancer in my country account for more than 80% of cancer deaths, which are the focus of cancer prevention an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K9/14A61K39/395A61P35/00
Inventor 朱宏杨治华冉宇靓
Owner 南京伍盛纳米科技有限公司
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