Efficient liquid-phase chromatograph and thin-layer chromatograph radioactive isotope detecting instrument

Abstract

The detecting instrument includes a detector with its DC high voltage being supplied by high voltage circuit. The detector is setup inside a shield. There is a slit on base of the shield for ray to enter into. The detector is connected to amplifying and shaping circuit composed of linear pulse amplifier and CR-RC shaping circuit. The amplifying and shaping circuit is connected to pulse height analyzer, which is connected to integrating amplifier controlled by single chip. The integrating amplifier carries out integral amplification for pulse outputted from the pulse height analyzer so as to output proportioned linear signal of voltage to implement conversion between frequency-voltage. The detecting instrument can be connected to workstation of liquid chromatography. Using different adapters of shield, the disclosed instrument can be in use for detection of thin layer chromatography or detection of high performance liquid chromatography. Features are: easy of operation, high sensitivity and resolution.

Description

technical field [0001] The invention belongs to a radioactive isotope measuring instrument. Background technique [0002] Radionuclide and labeled compound tracer technology has been widely used in the medical field. In order to determine the chemical purity of radiopharmaceuticals, understand the principle of drug action, study drug metabolism and other applications, it is necessary to separate different chemical components and measure their radioactivity. Separation methods include paper chromatography, thin layer chromatography, high performance liquid chromatography, etc. In the past, after separation of radiopharmaceuticals, most of them used the segmented measurement method, that is, the paper strips after the radiopharmaceutical chromatography was developed were cut into multiple segments, and then the radioactivity of each segment was measured separately with a ray detection instrument. These radiation detection instruments have different purposes, such as some use...

AI Technical Summary

Problems solved by technology

These ray detection instruments have different uses, such as some use gamma counters, some use portable dosimeters, so they cannot meet the high count rate requirements of chromatographic analysis, and it is inconvenient to measure radioactivity separated by other separation methods.

Since this method needs to manually cut paper strips and put them into test tubes for measurement, the operation is inconvenient and human errors are large, resulting in low sensitivity and resolution

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