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Composition for inhibition or prevention of bone density lowering and refreshment therefor

A composition, a technology of bone mineral density, applied in the composition for treating or improving osteoporosis, food and drink for treating or improving osteoporosis, and the field of prevention, capable of solving the problem that there is no bone resorption inhibitory activity of isohopone To achieve excellent results, increase bone mineral density, and avoid side effects

Inactive Publication Date: 2006-06-21
KIRIN BREWERY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this paper, there is no clear evidence that isohopones have inhibitory activity on bone resorption

Method used

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  • Composition for inhibition or prevention of bone density lowering and refreshment therefor
  • Composition for inhibition or prevention of bone density lowering and refreshment therefor
  • Composition for inhibition or prevention of bone density lowering and refreshment therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0111] The following examples are to further illustrate the present invention, but not to limit the scope of the present invention.

[0112] Preparation Example

Embodiment A

[0113] Embodiment A: the purification of isoxanthohumol

[0114] The example described below is extracted from beer (KIRIN LAGER BEER (trade name), produced by Kirin Brewery Co., LTD. (Japan)) (hereinafter simply referred to as "beer"), and powdered hops with a high xanthohumol content Purification of isoxanthohumol was carried out in Xanthohumol Enriched Product (trade name) and Xantho-pure (trade name), both produced by Hopsteiner).

[0115] Purified from beer

[0116] The beer (1000ml) was degassed and an 800ml portion was extracted with 1000ml of diethyl ether. The diethyl ether phase was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Then, 20 ml of ethyl acetate was added, and the mixture was dehydrated over anhydrous sodium sulfate, and concentrated to about 1 ml under reduced pressure. The concentrate was fractionated by column chromatography on silica gel (Kieselgel 60, 10 g). The column was washed with 30% ethyl acetate / n-hexane, and...

Embodiment B

[0142] Example B: Isomerization of hop extract

[0143] A commercially available hop extract (Xantho-pure (trade name)) (18 g) having a xanthohumol content of about 80% was dissolved in 2 L of ethanol. To the solution was added weakly alkaline (pH 8.5 to 9.5) bottled water (Arukari lon no Mizu (ionized alkaline water) (trade name), manufactured by KIRIN BEVERAGE) (18 L). The mixture was heated under reflux at 92°C-93°C for 2 hours for thermal isomerization. Next, insoluble matter was filtered off with filter paper. The filtrate was then concentrated under reduced pressure, and the concentrate was lyophilized. Lyophilization yielded about 18 g of powdered isomerized hop extract. The isoxanthohumol content of powdered isomerized hop extract is about 70%.

[0144] Purification by the same method as in Example A "purification from hop extract (2)" can provide isoxanthohumol with a purity of not less than 98%.

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PUM

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Abstract

A composition for inhibiting or preventing bone density loss, comprising isoxanthohumol or isomerized hop extract as an active ingredient; or foods and beverages for this purpose. Using such compositions or foods and beverages, it is possible to inhibit or prevent bone density loss while avoiding side effects that may occur when using estrogen preparations.

Description

technical field [0001] The present invention relates to compositions, foods and beverages for inhibiting or preventing bone density loss. More specifically, the present invention relates to a composition for preventing, treating or improving osteoporosis, and food and drink for preventing, treating or improving osteoporosis. Background technique [0002] Osteoporosis is a disease characterized by decreased bone mass and disturbance of the fine architecture of bone tissue, leading to increased bone fragility and fracture risk. Osteoporosis is becoming a worldwide serious health problem. One-third of menopausal women and most of the elderly (including men and women) suffer from osteoporosis. In Japan, for example, fractures related to osteoporosis are the third leading cause of "bedridden people" and one of the causes of inflated medical costs. In addition, it is considered that the development of an aging society has also produced a larger number of osteoporosis patients. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A23L1/30A23L2/38A23L2/52A61K36/185A61P19/10
CPCA61K31/12A61K36/185A23L33/105A61P19/00A61P19/10
Inventor 田岛修形山干生
Owner KIRIN BREWERY CO LTD
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