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Use of rhubarb anthraquinone compound in preventing and treating respiratory syncytial virus infectious disease

A technology for infectious diseases and syncytial virus, applied in the application field of rhubarb anthraquinone compounds in the prevention and treatment of respiratory syncytial virus infectious diseases, achieving the effect of rich natural resources, less toxic and side effects, and mature processing and extraction technology

Inactive Publication Date: 2006-10-11
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no safe and effective vaccine against RSV infection, so the research on anti-RSV drugs has become a topic of international medical attention in recent years.

Method used

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  • Use of rhubarb anthraquinone compound in preventing and treating respiratory syncytial virus infectious disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Rhubarb anthraquinones are made into injection rhubarb injection, the total anthraquinone content of rhubarb is 100mg / ml, each 2.0ml, clinically used to prevent and treat diseases caused by respiratory syncytial virus, usage: 2.0ml each time , intramuscular injection, intravenous injection or intravenous drip, 2 times a day, 5 days a course of treatment.

Embodiment 2

[0030] Example 2: rhubarb anthraquinone compounds were made into rhubarb tablets, the total anthraquinone content of rhubarb was 200mg / 0.5g / tablet, which was clinically used to prevent and treat diseases caused by respiratory syncytial virus. Usage 2-4 tablets each time, orally, 2-3 times a day, 7 days as a course of treatment.

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Abstract

The invention relates to an application of anthraquinones compound in preventing diseases infected by respiratory syncytial virus. The median poison concentration TC50 of anthraquinones compound for cell Hep-2 is 209.7 mg / ml; the median effective concentration LC50 for respiratory syncytial virus is 96.7 mg / ml; the treating index is 2.3; the inhibiting rate to cytopathic RSV cell is over 50% when drug concentration is over 128 ug / ml; and the larger of drug concentration, the higher of inhibiting rate. The side effect of nthraquinones compound is smaller than that of ribavirin, the process is simple and it can be prepared into various dosage forms.

Description

(1) Technical field: [0001] The invention relates to the application of rhubarb anthraquinone compounds, in particular to the application of rhubarb anthraquinone compounds in preventing and treating respiratory syncytial virus infectious diseases. (two) background technology: [0002] Respiratory syncytial virus (RSV) belongs to the genus Pneumovirus of the family Paramyxoviridae, which is the same genus as parainfluenza pathogens. They are both single-negative-sense RNA viruses and can cause upper and lower respiratory diseases. They are acute lower respiratory tract diseases in infants and young children. Infection with a common pathogen, almost all children under the age of 2 have been infected with RSV [8] . In recent years, RSV infection has been found to be an important virus in the elderly and immunosuppressed adults [9] . There is still no specific and effective treatment for RSV infection. The antiviral drug ribavirin (also known as Ribavirin, Ribavirin) has be...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K9/08A61K9/20A61P31/12
Inventor 罗伟生徐庆张奉学苏小建刘卫兵唐祖年梁荣感李丽亚韦京辰
Owner GUILIN MEDICAL UNIVERSITY
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