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Application of rhizome of Common Burreed in preparation of medicament for curing virosis

A technology for AIDS and use, applied in the prevention and treatment of AIDS, the active extract of Vitex trigonum plant, in the field of preparation of drugs for the treatment of viral diseases, can solve the problems of prevention and treatment of AIDS that have not yet been seen, and achieve low environmental impact, rich natural resources, and regeneration powerful effect

Inactive Publication Date: 2011-05-18
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports about Jing Sanleng's prevention and treatment of AIDS

Method used

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  • Application of rhizome of Common Burreed in preparation of medicament for curing virosis
  • Application of rhizome of Common Burreed in preparation of medicament for curing virosis
  • Application of rhizome of Common Burreed in preparation of medicament for curing virosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 500 g of Vitex trigonum tuber, pulverized, extracted with 8 times the amount of 95% ethanol under reflux for 2 hours, filtered with suction, and extracted once with the dregs in the same way. The two extracts were combined and concentrated to obtain 30 g of extract. The extract is suspended with 2 times the amount of water, extracted twice with the same amount of petroleum ether as the suspension, and then extracted twice with the same amount of ethyl acetate. The ethyl acetate extraction part was concentrated under reduced pressure to obtain 6 g of extract. This part is the part where the effective components Scirpusin A and B are concentrated, and the content of Scirpusin A and (or) Scirpusin B is 5%, which can be used as the effective part of the trigonum trigonum.

Embodiment 2

[0023] 500 g of Vitex trigonum tuber was pulverized and reflux extracted with 85% aqueous acetone for two hours each time. The two extracts were combined and concentrated under reduced pressure at 60° C. to obtain 42 g of extract. Mix the extract with 2 times the amount of 100-200 mesh silica gel, and perform column chromatography on 30 times the amount of silica gel (100-200 mesh). Gradient elution was carried out with cyclohexane-ethyl acetate (volume ratio 3:1 and 1:5) and ethyl acetate. Collect cyclohexane-ethyl acetate (1:5) eluted fractions, concentrate under reduced pressure to 2.8 g of amorphous solids, mainly containing Scirpusin A and B, and the content of Scirpusin A and (or) Scirpusin B is 10%, which can be It is used as the effective part of Jing San Leng.

Embodiment 3

[0025] 500 g of the tubers of Jing San Leng were pulverized, soaked with 80% ethanol at room temperature for 48 hours, and collected the cold soak; repeated 2 times, combined three cold soaks, and concentrated under reduced pressure at 60° C. to obtain 15 g of extract. The macroporous resin HP-20 on the extract was eluted with water, 10% ethanol, 30% ethanol and 80% ethanol respectively, and the eluted part of 30% and 80% ethanol mainly contained Scirpusin A and B, and concentrated under reduced pressure to obtain 4g of extract , the content of Scirpusin A and (or) Scirpusin B in this part is 7%, which can be used as the effective part of Vitex trigonum.

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Abstract

The invention relates to a new medicine application of Scirpus yagara which belongs to sedge family Scirpus, in particular to an application to preparing medicines which treat viral disease especially AIDS. The active site of the Scirpus yagara extract contains index components Scirpusin A and Scirpusin B and the content is no less than 5 percent. Experiments prove that the active site of the Scirpus yagara has obvious inhibited effect on virus, especially HIV virus and the effective concentration is 0.82 ug / ml, which is 10 times of that of monomeric compound scirpusin A or B. The active site can be applied solely or with other things, or combined with an excipient properly to be produced into peroral or parenteral liquid to be applied to preventing and treating viral disease especially the AIDS.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to a new medical application of a plant of the Cyperaceae syringaceae, specifically the active extract of the plant of the genus Vitex in the preparation of medicines for treating viral diseases. More specifically, the invention relates to the application of the active extract of the cloverleaf plant in the prevention and treatment of AIDS. technical background [0002] It is known that AIDS (full name: Acquired Immunodeficiency Syndrome) is caused by Human Immunodeficiency Virus. At present, a number of nucleosides such as AZT, ddc, ddI, and 3TC have been widely used in the treatment of AIDS. According to reports, these drugs are indeed effective in prolonging the life of patients and improving their quality of life. However, such drugs generally have severe side effects such as bone marrow toxicity, and at the same time, the emergence of AIDS drug-resistant virus strains has li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/89A61K31/343A61K9/08A61K9/16A61K9/20A61K9/48A61P31/18A61K125/00
Inventor 杨国勋胡昌奇周金涛
Owner FUDAN UNIV
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