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Tumor model and method

A tumor and model technology, applied in the field of life sciences, which can solve problems such as the lack of scientific research breakthroughs

Inactive Publication Date: 2006-11-08
叶新新
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0002] Modern medical science has carried out tumor science research at various scientific research levels for more than a century, aiming at lethal solid malignant tumors with the highest clinical natural incidence rate in the human population, such as lung cancer, gastric cancer, breast cancer, colorectal cancer, liver cancer... ; So far, no scientific research breakthroughs have been made to solve substantive problems in terms of effective prevention of cancer, effective radical cure or long-term effective remission therapy for middle-advanced lethal solid malignant tumors that have metastasized

Method used

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Embodiment Construction

[0009] In order to achieve the above object, implement the scheme that the present invention adopts:

[0010] 1. Preparation of biological experiment materials

[0011] 1.1.1 The mouse breast cancer MAC891 tumor strain established by the Cancer Institute of the Chinese Academy of Medical Sciences is a TA2 inbred mouse with a high natural incidence of breast cancer, and the spontaneous breast cancer tissue is continuously subcultured and transplanted into the same TA2 inbred line Subcutaneously in mice, the transplantable mouse type B2 breast cancer tumor strain was established. The incidence rate of the transplanted tumor strain was 100%; the survival time of the animals was 47 days.

[0012] 1.1.2 TA2 inbred mouse mammary carcinoma MAC891 xenograft tumor model: mouse mammary carcinoma MAC891 tumor strain according to 5×10 6 Cells / 0.2ml / dose per mouse were injected and inoculated in the axilla of 6 TA2 mice. After inoculating the transplanted tumor strains for 30 days to 35...

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Abstract

The present invention, tumor model and method, relates to life science and medicine technology. It provides one tumor model and method capable of revealing the comprehensive molecular tumor biological regulating and controlling mechanism of, the comprehensive molecular tumor biological responding mechanism of, the comprehensive molecular tumor biological preventing and treating mechanism of and medicine for human malignant solid tumor, and one comprehensive scientific human tumor model experiment platform. It also provides human molecular tumor protein expressing spectrum target capable of detecting and revealing the human small cancer-in-situ cell tissue; human molecular tumor protein expressing spectrum target capable of detecting and revealing tumor cell tissue growth and proliferation; and tumor related human gene expressing spectrum target.

Description

technical field [0001] The present invention relates to a method and drug capable of revealing the evolution and transformation of human solid malignant tumors and the microenvironment of body tissues or organs, the comprehensive molecular tumor biological regulation mechanism, the comprehensive molecular tumor biological response mechanism, the comprehensive molecular tumor biological prevention and treatment mechanism, and the drug. Models and methods, an experimental platform for scientific research on comprehensive tumor models. It can reveal the detection and monitoring of human small in situ cancer cell tissues, human-related molecular tumor proteome expression profile targets; reveal the human-related molecular tumor proteome expression profile targets, tumor-related human genes that antagonize-inhibit the growth and proliferation of human tumor cell tissues Expression profiling targets. It involves the fields of life sciences and medicine. Background technique [0...

Claims

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Application Information

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IPC IPC(8): A61K49/00C12N5/09C12Q1/68G01N33/68
Inventor 叶新新
Owner 叶新新