Preparation of allantoin and allantoin extract from cistanche salsa and their use thereof

A technology of allantoin and extract, which is applied in the field of extraction, separation and structure identification of chemical components of Chinese herbal medicine, and can solve problems such as application

Inactive Publication Date: 2006-11-15
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] All the allantoin used clinically is synthetic, and the allantoin or allantoin-containing extrac

Method used

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  • Preparation of allantoin and allantoin extract from cistanche salsa and their use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: Prepare allantoin extract or allantoin with Cistanche deserticola as raw material

[0008] Cistanche salsa (C.A.Mey) G.Beck 160g, extracted twice with 10 times and 8 times of water at 80°C respectively, combined the extracts, concentrated under reduced pressure to a thick paste (density at 50°C is about 1.1 g / ml), add ethanol to 60% alcohol content, let it stand overnight, concentrate the alcohol solution, add water to dissolve. The water liquid passes through the macroporous adsorption resin SP 825 Column (about 500ml in volume), eluted with water of 3 times of column bed volume, collected fractions containing allantoin in it, and then passed through granular activated carbon (about 300g), first eluted with water of 3 times of column bed volume, and then used Elute with 30% ethanol for 3 times the volume of the column bed, collect the fractions containing allantoin, concentrate under reduced pressure to a thick paste, then freeze-dry to obtain the allant...

Embodiment 2

[0009] Example 2: Confirmation of the structure of allantoin

[0010] The crystal obtained in Example 1, mp243~245°C, is easily soluble in water and dilute alcohol, and the alkaloid reaction is positive. IR(KBr)cm 1 : 3437, 3344 (NH 2 ); 3207, 3062 (NH); 1779, 1568 (C=O); 1602, 1528, 1430, 1183 (C-N); MS: 158 (M + ) indicates that the molecular structure has an even number N; 1 H-NMR (DMSO-d 6 )δppm: 5.25 (1H, d, J=8.1Hz, H-4), 5.76 (2H, s, H-8), 6.86 (1H, d, J=8.1Hz, H-6), 8.03 (1H, s, H-3), 10.51 (1H, s, H-1); 13 C-NMR (DMSO-d 6 ) δppm: 62.6 (C-4), 156.9 (C-2), 157.5 (C-7), 173.7 (C-5). Simultaneous injection with the synthesized allantoin in the HPLC instrument has the same retention time. The structural formula is as follows:

[0011]

Embodiment 3

[0012] Embodiment 3: the preparation of a kind of natural allantoin skin care cream

[0013] formula:

[0014] Acidi Stearici 100g

[0015] Cetyl Alcohol Cetylii Alcoholis 45g

[0016] Lanolin Adeps Lanae 10g

[0017] Propylene Glycol Glycolis Propylenici 150ml

[0018] Sodium Lauryl Sulfate Natrii Laurylis Sufatis 5g

[0019] Triethanolamine Triaethanolamini 7g

[0020] Vitamin E Vit E 0.5g

[0021] Natural Allantoin 10g

[0022] Or Allantoin extract or Allantoin extract Equivalent to 10 grams of Allantoin extract

[0023] Appropriate amount of water-soluble fragrance Esssenlce

[0024] Add deionized water to Aquae to 1000g

[0025] Preparation method:

[0026] 1. Take stearic acid, cetyl alcohol, lanolin and vitamin E, put them in a suitable container and heat at 70-80°C;

[0027] 2. Take propylene glycol, sodium lauryl sulfate, triethanolamine, water-soluble essence and water and heat it at 70-80°C in another suitable container. After the two liquids are at the ...

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Abstract

An allantoin and the component containing said allantoin are extracted from cistanche through separation with macroreticular adsorption resin and granular activated carbon. Said allantoin can be used to decrease blood fat.

Description

technical field [0001] The present invention relates to a technology for extracting, separating and identifying the chemical components of Chinese herbal medicine; and relates to the medical application of natural allantoin or allantoin extract in skin care, lowering blood fat, etc.; the present invention can also be applied to Cistanche deserticola The powder is qualitatively different from other Cistanche powder. Background technique [0002] In the past one or two decades, there have been hundreds of reports on the chemical components of Cistanche at home and abroad, and the number of compounds isolated from desert Cistanche alone has reached 69 (Edited by Liu Guojun. Cistanche and its artificial cultivation. Chinese labor Social Security Press, 2003.120), more than 40 compounds were also isolated from other species of Cistanche. Most of the ingredients are consistent with Desert Cistanche, related reports can be seen KobayashiH, et al.ChemPharm.Bull.1984, 32 (5); 1984, ...

Claims

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Application Information

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IPC IPC(8): C07D233/88A61K8/49A61K31/4166A61P3/06A61Q19/00G01N33/00
Inventor 堵年生杨建华热娜·卡斯木
Owner XINJIANG MEDICAL UNIV
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