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An arctium fruit extract, its preparation method and application

A technology of extract and burdock fruit, which is applied in the field of burdock fruit extract and its preparation, can solve the problems of unreported component composition and lack of precise positioning

Inactive Publication Date: 2006-11-22
SHANGHAI NUOREN BIOMEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have shown that Burdock Fructus has significant hypoglycemic and anti-diabetic nephropathy effects, but the active site with these two pharmacological effects has not been precisely located, and the composition of the active site has not been reported.

Method used

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  • An arctium fruit extract, its preparation method and application
  • An arctium fruit extract, its preparation method and application
  • An arctium fruit extract, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of burdock fruit extract, the preparation method of which is as follows: take the burdock fruit medicinal material, grind it into a coarse powder, add 5 times the amount of 50% ethanol, reflux extraction twice, each time for 3 hours, filter, combine the filtrates, concentrate under reduced pressure to concentrated leaching The paste has no alcoholic smell. The obtained liquid extract was allowed to stand at room temperature, the upper liquid part was poured off, the lower dry extract was suspended in water, and extracted with ethyl acetate until the extract was colorless. Concentrating the extract under reduced pressure into a dry extract, and vacuum-drying at 60° C. to obtain a dry powder of arctium fruit extract with a water content of less than 5%.

[0028] The burdock fruit extract dry powder is determined by ultraviolet spectrophotometry (see Example 5 of the present invention for specific operation), and the weight content of total lignans and arctiin is 51...

Embodiment 2

[0030] A kind of burdock fruit extract, the preparation method of which is as follows: take the burdock fruit medicinal material, grind it into a coarse powder, add 8 times the amount of 80% ethanol, reflux extraction 3 times, each time for 4 hours, filter, combine the filtrates, concentrate under reduced pressure to concentrated leaching The paste has no alcoholic smell. The obtained liquid extract was allowed to stand at room temperature, the upper liquid part was poured off, the lower dry extract was suspended in water, and extracted with ethyl acetate until the extract was colorless. Concentrating the extract under reduced pressure into a dry extract, and vacuum-drying at 60° C. to obtain a dry powder of arctium fruit extract with a water content of less than 5%.

[0031] The burdock fruit extract dry powder is determined by ultraviolet spectrophotometry (see Example 5 of the present invention for specific operation), and the weight content of total lignans and arctiin is ...

Embodiment 3

[0033] A kind of burdock fruit extract, the preparation method of which is as follows: take the burdock fruit medicinal material, grind it into a coarse powder, add 10 times the amount of 95% ethanol, reflux extraction twice, each time for 6 hours, filter, combine the filtrates, concentrate under reduced pressure to concentrated leaching The paste has no alcoholic smell. The obtained liquid extract was allowed to stand at room temperature, the upper liquid part was poured off, the lower dry extract was suspended in water, and extracted with ethyl acetate until the extract was colorless. Concentrating the extract under reduced pressure into a dry extract, and vacuum-drying at 60° C. to obtain the burdock fruit extract with a water content of less than 5%.

[0034] The burdock fruit extract dry powder is determined by ultraviolet spectrophotometry (see Example 5 of the present invention for specific operation), and the weight content of total lignans and arctiin is 65%-80%.

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Abstract

The invention relates to a burdock fruit extract, its preparing process and use thereof, wherein the extract comprises 51-80 wt% of total lignanoids compound with burdock aglycone as the main ingredient and burdock glycosides, and 20-49 wt% of other constituents.

Description

technical field [0001] The invention relates to an extract, its preparation method and application, in particular to a burdock fruit extract, its preparation method and application. Background technique [0002] At present, diabetes has become the third disease that seriously threatens human health after tumors and cardiovascular diseases, and is listed by WHO as one of the world's three major chronic diseases. Among diabetic patients, 30% to 40% of patients with type I diabetes with a course of more than 15 years have nephropathy, and this proportion of patients with type II diabetes is about 25%. irreversible. [0003] Arctium burdock is a traditional Chinese medicine recorded in the 2000 edition of the "Chinese Pharmacopoeia". It originally belonged to the category of pungent and cool-relieving traditional Chinese medicine. , measles, rubella, sore throat and other diseases, the dosage is 6-12g / day. [0004] Studies have shown that Burdock Fructus has significant hypog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K131/00A61P3/10A61P13/12
Inventor 徐朝晖贾伟邱明丰赵爱华
Owner SHANGHAI NUOREN BIOMEDICAL TECH
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