Cross reaction antigen computer-aided screening method
A computer-aided, cross-reactive technology, applied in computing, special data processing applications, instruments, etc., can solve the problems of no obvious improvement and low prediction efficiency.
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[0020] Such as figure 1 As shown, computer-aided screening of cross-reactive antigens between pathogenic microorganisms and human specific tissue cells requires five steps:
[0021] 1. Establish a data set of pathogenic microorganisms and human-specific tissue cells
[0022] The Swiss-Prot protein database can be downloaded from the server of Peking University, address: ftp: / / cn.expasy.org / . The condition for searching all proteins of a certain pathogenic microorganism is: OG=English name of pathogenic microorganism; searching for all proteins of human-specific tissue cells is: OG=homo sapiens; TissueSpecificity=English name of tissue cells. Convert to FASTA format after searching. All of the above can be realized through perl programming. For human-specific tissue cell proteins, manual screening is required after the search to ensure the correctness of the data set;
[0023] 2. Establish a data set of B cell linear epitopes
[0024] B cell linear epitopes are split into ...
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