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Angiotensin II receptors I immunogenic peptide section and its use

An angiotensin and immunogenic technology, applied in the antihypertensive treatment of essential hypertension, the compound field of new immunological treatment of essential hypertension, can solve the problem of not being able to lower the blood pressure of adult SHR, and achieve effective control Effects of blood pressure and compliance improvement

Active Publication Date: 2007-01-17
WUHAN HUAJIYUAN BIOTECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Zelezna B et al. (2) use AT 1 Receptor extracellular N-terminal peptide fragment (amino acid sequence is SEQ ID NO: 14-23), actively immunized spontaneously hypertensive rats (SHR), and all animals produced antibodies against the peptide after 5 months, reducing Reduced elevated blood pressure levels in juvenile SHRs but failed to reduce already elevated blood pressures in adult SHRs

Method used

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  • Angiotensin II receptors I immunogenic peptide section and its use
  • Angiotensin II receptors I immunogenic peptide section and its use
  • Angiotensin II receptors I immunogenic peptide section and its use

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Embodiment Construction

[0015] The invention provides an AT for immune targeting treatment of essential hypertension 1 The peptide segment of the receptor antihypertensive vaccine, the amino acid sequence of the peptide segment is SEQ ID NO: 181-187 and its variants; the composition comprising the peptide segment and a physiologically acceptable carrier, and the peptide segment is coupled to the carrier protein , and the conjugated peptide molecule is prepared with an appropriate adjuvant to prepare a peptide vaccine.

[0016] At the same time, it provides the use and method of the peptide for treating essential hypertension, including administering an effective dose of vaccine. Administration procedures include standard intramuscular and subcutaneous routes and procedures, and the amount of peptide administered can be selected according to the formulation and the hypertensive state to be treated.

[0017] The invention belongs to the fields of biotechnology medicine and biotherapeutics, and relates...

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Abstract

An angiotensin IIreceptorI-type immune peptide section and its use are disclosed. The peptide section is selected from the amino-acid sequence as following: SEQ ID NO:181-187, amino-acid sequence of peptide section is Ala-Phe-His-Tyr-Glu-Ser-Arg; its analog is Ala-Phe-His-Tyr-Glu-Ser-Gln. It has excellent treatment performance, antigenicity and / or immunodominance. The use is carried out by feeding medicine by injecting for 0-8weeks. It can be used to treat primary hypertension as vaccine or medicinal composition.

Description

technical field [0001] The invention relates to an angiotensin II receptor type 1 immunogenic peptide and its application. The invention belongs to the fields of biotechnology medicine and biotherapeutics, and relates to a compound used for novel immunological treatment of essential hypertension. The invention particularly relates to angiotensin II receptor type 1 (AT1) immunogenic peptides and vaccines and pharmaceutical compositions prepared with the peptides, which can be used for the antihypertensive treatment of essential hypertension. Background technique [0002] Hypertension is a disease with a high incidence that seriously endangers human health, affecting 1 billion people worldwide. The Framingham Heart Study suggests that 90% of people with normal blood pressure at age 55 are likely to develop high blood pressure during their lifetime. Hypertension is an independent risk factor for cardiovascular and cerebrovascular diseases. Effective control of blood pressure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61K39/00A61P9/12
Inventor 廖玉华李留东朱峰周子华魏宇淼王敏魏芬陈明程翔
Owner WUHAN HUAJIYUAN BIOTECH DEV
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