Ultrasound and MRI combined contrast medium and preparation method thereof

A magnetic resonance contrast agent and contrast agent technology, applied in the field of ultrasound and magnetic resonance contrast agents, can solve problems such as uncertain diagnosis, inconspicuous contrast of ultrasound images, and lack of enhanced information

Inactive Publication Date: 2007-04-25
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Contrast-enhanced ultrasonography may lack enhancement information due to the contrast part being covered by tissue or the contrast of the ultrasound image is not obvious, making the diagnosis uncertain

Method used

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  • Ultrasound and MRI combined contrast medium and preparation method thereof

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specific Embodiment 1

[0029] Specific implementation example 1: the composition of the prescription of the combined contrast agent

[0030] Recipe composition 1 (upper limit composition)

[0031] Carboxymethyl starch modified superparamagnetic Fe 3 o 4 Nanoparticles 1g

[0032] Polyethylene glycol (PEG) 100g

[0033] Tween 80 30g

[0034] Span 80 30g

[0035] Rb40.34 anti-P-selective protein antibody 10μg

[0036] Biotin 5.5μg

[0037] Avidin 5.5μg

[0038] Perfluoropentane 5g

[0039] Deionized water total 1000ml

[0040] Formula composition 2 (lower limit composition)

[0041] Carboxymethyl starch modified superparamagnetic Fe 3 o 4 Nanoparticles 0.4g

[0042] Polyethylene glycol (PEG) 30g

[0043] Tween 80 10g

[0044] Span 80 10g

[0045] Rb40.34 anti-P-selective protein antibody 5μg

[0046] Biotin 1.5μg

[0047] Avidin 1.5μg

[0048] Perfluoropentane 1g

[0049] Deionized water total 1000ml

[0050] Recipe Composition 3 (Best Point Composition)

[0051] Carboxymethyl starc...

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Abstract

The invention relates to a method for preparing ultrasonic magnetic resonance couple contrast agent. Wherein, it uses modified macromolecule polymer bubble case and the couple contrast agent that packs the magnetic contrast agent and biological active gas. The contrast agent is formed by bubble case of modified macromolecule polymer to pack magnetic resonance contrast agent and biological active gas, while the bubble case comprises macromolecule polymer, target antibody, surface activator; and in the couple contrast agent, as mass percentages, the macromolecule polymer is 10-30%, the carbowax is 1-10%, the surface activator is 0.01-5%, the target antibody is 5-10%, the magnetic resonance contrast agent is 0.4-1%, the biological active gas alorbatalotane is 1-5%m and the left is solvent. The invention can improve the stability and effect.

Description

technical field [0001] The invention relates to ultrasound and magnetic resonance contrast agents, in particular to a combined contrast agent composed of modified high molecular polymer capsule shells and wrapped magnetic contrast agents and bioactive gases and a preparation method thereof. Background technique [0002] Ultrasound contrast agent (UCA) is a class of diagnostic agents that can significantly enhance medical ultrasound detection signals. In the detection and imaging of human microvascular and tissue perfusion, the use of UCA has good imaging effects, real-time, convenient operation, and ion-free Radiation, non-destructive, wide application and other advantages. The basic point of ultrasound contrast agents is to use gas as a reflection-enhancing medium. After the first generation of free microbubble contrast agent and the second generation of air-encapsulated microbubble contrast agent, the third generation of new acoustic contrast agent uses polymer fluorocarb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/16
Inventor 顾宁杨芳吉民张宇
Owner SOUTHEAST UNIV
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