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Externally applied transdermal Chinese medicinal formulation for treating skin cancer

A transdermal preparation and skin cancer technology, applied in the field of transdermal preparations for external use of traditional Chinese medicine, can solve the problems of transdermal preparations for external use of traditional Chinese medicine that have no curative effect on skin cancer, and achieve significant anti-tumor effects, inhibit cell proliferation, and have definite curative effects

Inactive Publication Date: 2007-05-16
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no external transdermal preparation of traditional Chinese medicine with definite curative effect and convenient use in the treatment of skin cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of Curcuma Supercritical Extract:

[0045] Weigh 8 kg of zedoary coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and adjust the pressure of the extractor and the flow rate of carbon dioxide through the joint adjustment of the back pressure valve and the high-pressure pump speed to maintain the set parameters, that is, the extraction pressure is 19MPa, and the extraction flow rate is 4.8kg / m 2 s; According to the fluctuation of pressure and flow, adjust the temperature of the heating system, maintain the temperature of the extractor at 50°C, keep the system stable, and reflux extraction for 3 hours to obtain the supercritical extract of Zedoary Curcuma with good fluidity and darker color.

Embodiment 2

[0047] Preparation of Curcuma Supercritical Extract:

[0048] Weigh 8 kg of zedoary coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and adjust the pressure of the extractor and the flow rate of carbon dioxide through the joint adjustment of the back pressure valve and the high-pressure pump speed to maintain the set parameters, that is, the extraction pressure is 25 MPa, and the extraction flow rate is 1.2kg / m 2 s; According to the fluctuation of pressure and flow, adjust the temperature of the heating system, maintain the temperature of the extractor at 35°C, keep the system stable, and reflux extraction for 1 hour to obtain the supercritical extract of Zedoary Curcuma with good fluidity and darker color.

Embodiment 3

[0050] Preparation of Curcuma Supercritical Extract:

[0051] Weigh 8 kg of zedoary coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain the optimized parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, that is, the extraction pressure is 22 MPa, and the extraction flow rate is 1.8kg / m 2 s; According to the fluctuation of pressure and flow, adjust the temperature of the heating system, maintain the temperature of the extractor at 45°C, keep the system stable, and reflux extraction for 1.5 hours to obtain the supercritical extract of Zedoary Curcuma with good fluidity and dark color.

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Abstract

The invention discloses an externally-used Chinese transdermal preparation for treating skin cancer which mainly comprises supercritical extract of curcuma zedoaria rose, and can effectively inhibit skin cancer cells from proliferation with the advantages of precise curative effect, easiness in use, and non- toxicity and side actions.

Description

technical field [0001] The invention relates to an external transdermal preparation of traditional Chinese medicine, in particular to an external transdermal preparation of traditional Chinese medicine for treating skin cancer. Background technique [0002] Skin cancer refers to squamous cell carcinoma and basal cell carcinoma that occur in the skin, in addition to adnexal carcinoma such as sweat gland carcinoma, carcinoma in situ, melanoma, etc. Modern medicine thinks that the cause of the disease is not yet clear, and it may be related to skin diseases and physical and chemical stimuli such as radiation such as ultraviolet rays and X-rays. In TCM clinical practice, most of them belong to the category of "Fanhua", "Stone Boil" and "Black Boil". They are long-term lingering evils caused by wind, poison, dryness and heat, resulting in dry liver and blood, and malignant sores on the skin. Treatment methods include surgical resection, radiation and Laser and cryosurgery, intra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/70A61K9/06A61P35/00A61M37/00
Inventor 沈平孃刘志远肖琼汤秀珍蓝闽波林志宏齐春华杜晨捷赵明张继全
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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