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Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect

a technology of thymic peptide and immunological activity, which is applied in the field of synthetic, statistic thymic peptide combination and its use as immunologically and/or endocrinologically active preparations, can solve the problems of reducing the protective function of skin as well as the quality of hair and nail growth in humans, and the risk of contamination of organic extracts from animals with prion proteins, so as to achieve superior activity and eliminate the risk of bs

Inactive Publication Date: 2001-12-27
KLETT LOCH LORE MARIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012] It is possible to produce such thymic peptide combinations in a pharmaceutically reproducible sterile manner, so that a preparation results in this manner, which depending on the number of repeated statistic synthesis operations consists of a family of signaling thymic peptides characteristic of neurotransmitters and immunologically active signaling molecules. Based on analytical tests in comparison with partial hydrolysis mixtures from natural thymus tissue, it was possible to demonstrate that, within the margin of error of applied analytical methods, synthetic, statistic thymic peptide combinations are comparable in their composition with the natural preparation. From this follows that it was possible to accomplish the object of the present invention to eliminate the BSE risk by synthesizing a thymic peptide combination.
[0013] Surprisingly, it has shown that the synthetic preparation of the present invention exhibits in the biological test on human lymphocytes a superior activity with respect to mitogenic co-stimulation (induction of cell proliferation) in comparison with a commercial thymic preparation produced by partial hydrolysis.

Problems solved by technology

Moreover, humans exhibit a reduced protective function of the skin as well of the quality of hair and nail growth.
However, in the last five years the risk has come to the fore that such preparations of organic extracts from animals are contaminated with prion proteins.

Method used

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  • Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect
  • Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect
  • Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect

Examples

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example 1

[0023] The statistic thymic peptide combinations of the present invention were examined for bioactivity in the test system of the mitogenic co-stimulation in comparison with a commercial thymic preparation from partial hydrolysis. Tested were end concentrations of 100, 50, and 25 .mu.g / ml.

[0024] In the case of two donors (KFG and WH) the statistic thymic peptide combination shows a statically significantly higher bioactivity than a commercial thymic preparation from partial hydrolysis. While at the high concentration of 100 .mu.g / ml, an inhibition of cell proliferation was observed for a commercial thymic preparation from partial hydrolysis, the statistic thymic peptide combination led to a dose-dependent increase in the proliferation of human lymphocytes.

[0025] From two blood donations, human peripheral blood lymphocytes were isolated, and the proliferation rate of these cells was measured, after a suboptimal prestimulation (0.5 .mu.g / ml phytohemagglutinin (PHA)) under the action o...

example 2

[0032] The following example relates to the stimulation of the blood lymphocytes of donor DB. The test data are to be related with reference to FIGS. 3 and 4 to the result of the control formulation after adding phytohemagglutinin at PHA. The thymosin fraction No. 5 (TF5) was used as positive control in two concentrations (third and fourth columns from the left). For a comparison, a commercial partial thymic hydrolysate (fifth and sixth columns) was also used in the same concentration. As a control PHA was used alone.

[0033] In the mitogenic co-stimulation with suboptimal stimulation of the blood cells with PHA of 0.05 .mu.g / ml, the synthetic-statistic thymic peptide combination shows a surprisingly distinct activity both in the case of a dose of the claimed synthesized product of 100 .mu.g / ml / cell culture formulation and in the case of 0.4 .mu.g / ml / cell culture formulation.

[0034] Likewise, in the case of a slight prestimulation of the blood cells with PHA in an amount of 0.025 .mu.g...

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Abstract

Immunologically and / or endocrinologically active preparation containing as an active ingredient short-chain peptides with a weighted quantity ratio and a pattern of amino acids characteristic of thymus tissue.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001] This application is a continuation of U.S. application Ser. No. 09 / 424,625, filed Nov. 24, 1999 which is a U.S. National Phase application of PCT / DE97 / 01061, filed May 26, 1997. The contents of the above applications are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002] The invention relates to a synthetic, statistic thymic peptide combination and its use as an immunologically and endocrinologically active preparation.BACKGROUND OF THE INVENTION[0003] From an increasing number of scientific publications, it becomes obvious that a communication exists by means of low-molecular signaling substances between the brain, the organs of the immune system (bone marrow, thymus, lymph nodes, spleen, intestinal mucosa, pulmonary epithelium, and body skin) and the endocrine system of the hormonal control. From the thymic tissue, low-molecular proteins, so-called signaling peptides, were identified, which function both on...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/26A61K38/00A61P37/04
CPCA61K35/26A61K38/00Y10S930/18A61P37/04
Inventor KLETT-LOCH, LORE MARIA
Owner KLETT LOCH LORE MARIA
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