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Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods

a technology of nucleic acid molecules and polypeptides, applied in the field of cardiac diseases, can solve the problems of severe complications and its effects often becoming more physiologically severe, and achieve the effects of preventing or ameliorating the effect of gridlock deficiency

Inactive Publication Date: 2006-04-06
THE GENERAL HOSPITAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a new gene called gridlock and its encoded protein. The gene and protein play a role in the development and modeling of vascular disease. The invention provides methods for diagnosing, treating, and preventing gridlock-related diseases and conditions. The invention also includes a new nucleic acid molecule that encodes a gridlock polypeptide, as well as a vector and non-human animals that contain the gene. The invention also provides an antibody that specifically binds to a gridlock polypeptide. The invention can be used to diagnose and treat gridlock-related diseases in humans.

Problems solved by technology

The aorta, the main trunk of the systemic arterial network, is subject to several congenital and acquired disorders, that may lead to severe complications in infancy and adulthood.
Its effects often become more physiologically severe at birth, when closure of the ductus can exacerbate the restriction to aortic blood flow.

Method used

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  • Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
  • Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
  • Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods

Examples

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Embodiment Construction

[0070] The invention provides gridlock genes, which play a role in vascular development and modeling, polypeptides encoded by these genes, nucleic acid molecules related to these genes (see below), and diagnostic and therapeutic methods employing these genes, polypeptides, and nucleic acid molecules. The invention also provides methods for identifying compounds that modulate the biological activities of gridlock genes and polypeptides, and therapeutic methods employing these compounds.

[0071] The diagnostic, therapeutic, and screening methods of the invention are first described, followed by general approaches that can be used in carrying out these methods. Finally, experimental results supporting the methods of the invention are described.

Diagnostic Methods Employing gridlock Nucleic Acid Molecules, Polypeptides, and Antibodies

[0072] gridlock nucleic acid molecules, polypeptides, and antibodies can be used in methods to diagnose or monitor diseases and conditions involving mutat...

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Abstract

The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.

Description

PRIORITY INFORMATION [0001] This application is a divisional of, and claims priority from, U.S. Ser. No. 10 / 364,012, filed Feb. 10, 2003 (pending), which is a divisional of, and claims priority from, U.S. Ser. No. 09 / 705,534, filed Nov. 3, 2000 (U.S. Pat. No. 6,558,932), which claims priority from U.S. Ser. No. 60 / 163,903, filed Nov. 5, 1999 (now abandoned).STATEMENT AS TO FEDERALLY SPONSORED RESEARCH [0002] This research has been sponsored, in part, by grant numbers HL07208, RO1-RR0888, RO1-DK55383, and RO-HL49579 from the National Institutes of Health. The government may have certain rights in the invention.FIELD OF THE INVENTION [0003] This invention relates to cardiovascular diseases. BACKGROUND OF THE INVENTION [0004] The vascular system contains vessels that are morphologically and functionally distinct. For example, arteries carry oxygenated blood at high pressure from the heart, while veins serve as capacitance vessels for blood return. While some of the differences within t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C07H21/04C12P21/06A61K39/395C07K14/47C07K16/18A01K67/027A61K31/7088A61K35/12A61K35/76A61K38/00A61K48/00A61P9/00A61P9/10C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09G01N33/15G01N33/50G01N33/53G01N33/566
CPCA61K38/00C07K14/47C07K16/18A61P9/00A61P9/10
Inventor FISHMAN, MARKZHONG, TAO
Owner THE GENERAL HOSPITAL CORP
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