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Prostate cancer point of care diagnostics

a prostate cancer and diagnostic technology, applied in the field of point of care diagnostic disposables, can solve the problems of difficulty in urination, problems during sexual intercourse, or erectile dysfunction, and the total cost of prostate cancer treatment in the u.s. amounts to several billion dollars per year, and achieves the effects of easy exchange, rapid and easy reprogramming of the card, and demonstrated long-term stability

Active Publication Date: 2013-10-17
BOARD OF RGT THE UNIV OF TEXAS SYST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a system called a "Programmable Bio-Nano-Chip" that can be used to improve point-of-care in vitro diagnostics. The system can be re-tasked for different applications by adding specific molecular code. The system uses nano-nets to capture biomarkers and quantum dots to increase signal generation. The system can also mass produce the sensor elements in a cost-effective way. The patent specifically mentions prolactin, a hormone produced by the pituitary that has been linked to prostate cancer, and how the system can be used to measure and extract the bio-signatures associated with disease progression.

Problems solved by technology

Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers, where the cancer cells metastasize (spread) from the prostate to other parts of the body, particularly the bones and lymph nodes.
Prostate cancer may cause pain, difficulty in urinating, problems during sexual intercourse, or erectile dysfunction, and other symptoms can potentially develop during later stages of the disease.
Further, the total cost of treating prostate cancer in the U.S. amounts to several billion dollars per year.

Method used

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  • Prostate cancer point of care diagnostics
  • Prostate cancer point of care diagnostics
  • Prostate cancer point of care diagnostics

Examples

Experimental program
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Effect test

example 1

Muliplex Test

[0069]Sandwich antibody assays have been developed and multiplexed as a panel (FIG. 2) using reagents shown in Table 2. These were identified as optimal antibody reagents towards tests for PSA, complexed-PSA, and free-PSA on the P-BNC system. The promising biomarker complexed-PSA was developed as a replacement of the biomarker pro-PSA, because the reagents for pro-PSA (pending FDA approval) have not yet been released by the sole provider, but either marker can be used. The chip panel also includes internal (positive and negative) controls, as well as calibrators for the optical sensor analyzer.

TABLE 2Optimized ReagentsDetectionCapture AntibodyStandard AntigenAntibodyCoated on beadFor proof of concept and doseConjugated toBiomarkersensorscurveAlexafluor488Total PSATotal PSA mAbArtificial combinations of free PSATotal PSA mAb,Clone M212091,and PSA-ACT standards in PBSClone 5A6 Cat#Cat# 10-P20CProMedDX Patient PSA SerumMBS311572(Fitzgerald)Samples(MyBioSource)Sunnylab Pati...

example 2

Risk Calculator

[0077]The Prostate Cancer Prevention Trial Risk Calculator (prostate-cancer-risk-calculator.com) was developed as an outgrowth of the observation that PSA cannot be used as a dichotomous predictor of prostate cancer risk (e.g., PSA10 ng / mL=elevated), but that PSA is linearly related to risk of cancer as well as risk of high grade, potentially-lethal disease. Thus, researchers developed a multi-variable risk assessment tool that predicts the risk of prostate cancer and risk of high grade disease for an individual patient. This tool is used world-wide for risk assessment of men who are considering prostate biopsy.

[0078]More recently, our group added other biomarkers and risk variables (e.g., biomarkers: PCA3, percent free-PSA, proPSA, body mass index (BMI) and finasteride use) to the risk calculator and these have led to more precise and updated risk assessment.

[0079]Several of these biomarkers are only approved for certain ranges of PSA. For example, percent free-PSA, ...

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Abstract

The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.

Description

PRIOR RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application 61 / 412,994, filed Nov. 12, 2010, and expressly incorporated by reference in its entirety.FEDERALLY SPONSORED RESEARCH STATEMENT[0002]None.FIELD OF INVENTION[0003]The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer.BACKGROUND OF THE INVENTION[0004]Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers, where the cancer cells metastasize (spread) from the prostate to other parts of the body, particularly the bones and lymph nodes. Prostate cancer may cause pain, difficulty in urinating, problems during sexual intercourse, or erectile dysfunction, and other symptoms can potentially develop during later stages of the disease.[0005]Rates of detection of prostate...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/68
CPCG01N33/689G01N33/54386G01N33/57434C40B40/10
Inventor MCDEVITT, JOHN T.CHRISTODOULIDES, NICOLAOSFLORIANO, PIERRE N.THOMPSON, IAN
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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