52 results about "Prostate biopsy" patented technology

An apparatus and method for the insertion of a medical tool, for example a needle, within the human body. The apparatus and method are particularly useful in prostate brachytherapy and in prostate biopsy. The apparatus comprises a telescoping guide universally coupled to a first and second positioning means that are used to automatically and / or manually position the guide at a desired needle insertion trajectory. Automatic positioning of the guide is accomplished with reference to three-dimensional transrectal ultrasound images that can also be used to show needle insertion in real-time. The apparatus may be manually positioned in the approximate insertion trajectory and then a computer interconnected with the apparatus may be used to achieve the final trajectory based upon the ultrasound images. The apparatus is particularly useful in cases where multiple needles are to be inserted into a small target area and in cases where pubic arch interference prevents direct access to the target area.

The present invention provides a method and apparatus to insert a needle through a predetermined trajectory and with a predetermined depth, in order to reach a target accurately within soft tissue, under ultrasound imaging guidance. The invention can be applied to carry out, for example, prostate biopsy, or prostate brachytherapy. The apparatus can guide a biopsy needle into defined sites in the prostate gland. A conical approach is used to reach the prostate through one or more pivot points on the perineal wall. The biopsy needle penetrates the patient's skin through the pivot point for multiple cores. The apparatus holds a needle sheath with two ball joints. The orientation of the needle sheath is controlled by locking the front ball joint at the pivot point, and moving the back ball joint on a virtual plane. The biopsy needle is inserted manually through the needle sheath. The depth of the insertion is controlled by the position of the stopper on the biopsy gun holder. Both the orientation and depth stopper are preferably driven by motors.

The invention presents tools to improve a 3-D image aided biopsy or treatment procedure for prostate gland by providing additional functionality and additional visual cues on an output image of the prostate, which may be generated substantially in real-time. The tools include i) the identification of various parts of prostate to classify as per regular classification in pathological reports, ii) Computing and displaying the insertion depth of needle with respect to a selected target point during the procedure, iii) Computing and displaying the distance from needle tip to prostate surface following a procedure and, iv) Calibration for misalignment of a 2-D imaging transducer when used under tracked motion for a procedure.

The invention presents tools to improve a 3-D image aided biopsy or treatment procedure for prostate gland by providing additional functionality and additional visual cues on an output image of the prostate, which may be generated substantially in real-time. The tools include i) the identification of various parts of prostate to classify as per regular classification in pathological reports, ii) Computing and displaying the insertion depth of needle with respect to a selected target point during the procedure, iii) Computing and displaying the distance from needle tip to prostate surface following a procedure and, iv) Calibration for misalignment of a 2-D imaging transducer when used under tracked motion for a procedure.

A method and apparatus are disclosed for performing software guided prostate biopsy to extract cancerous tissue. The method significantly improves on the current system by accelerating all computations using a graphical processing unit (GPU) keeping the accuracy of biopsy target locations within tolerance. The result is the computation of target locations to guide biopsy using statistical priors of cancers from a large population, as well as based on previous biopsy locations for the same patient, and finally via mapping protocols with predefined needle configurations onto the patient's current ultrasound image.

The invention relates to a cantilever prostate biopsy robot comprising a prismatic pair and a revolute pair. A large arm, a small arm, a biopsy needling platform, a base and parallelogram connecting rods are connected through a triangular connector to form two parallelogram mechanisms connected in parallel, so that the biopsy needle platform can be horizontal constantly. The length direction of the prismatic pair is perpendicular to the plane of two rotary joint mechanical arms. A drive motor for rotary joints is mounted on the base; the base is mounted on a moving slider of the prismatic pair. The axis of the drive motor for rotary joints and the rotation axis of the large arm are superposed. The small arm, the large arm, a small arm crank and a small arm connecting rod form one parallelogram mechanism which transmits power and motion of a small arm drive motor to the small arm so that the small arm is driven. The weight of the drive motor for a small arm joint is transferred to the base, the weight of a cantilever is deceased, rotational inertia of driving a joint around the large arm is decreased, and the robot is higher in response speed and load-to-weight ratio.

The present disclosure relates to methods for the early detection of ERG over-expression, gene rearrangements, and diagnosis and / or prognosis of prostate cancer using a combined ERG IHC-FISH assay.

The invention discloses an automatic ultrasonic-guidance prostate biopsy particle implanting system and an acupuncture method. A positioning module is fixed on a support platform, an image acquiring module is fixed on the support platform, and an operation module is mounted on the positioning module. The image acquiring module comprises an ultrasonic probe, a probe support and a head sleeve, the ultrasonic probe is movably arranged on the probe support, and the head sleeve is fixedly arranged in front of the ultrasonic probe; the operation module can be horizontally and uniformly inserted into a prostate focus by the positioning module, or can be diagonally inserted into the prostate focus by avoiding pubis or urethral canal in a manner of single or multiple tapered radiations. By adopting the positioning platform of six degrees of freedom, the automatic ultrasonic-guidance prostate biopsy particle implanting system can realize bi-cone coverage and be inserted into the focus parallelly or in any cone-shaped by avoiding pubis and other organs; by combining nuclear magnetic resonance / ultrasound images with image display and ultrasound in real time, biopsy positions can be accurately and visually identified, so that positioning is more accurate.

An MR-guided biopsy, for example, prostate biopsy, is performed by a mechanical tool for stabilizing the patient in prone position and for guiding the biopsy needle into defined targeted lesions in the prostate gland. The patient can lay prone in the MRI. The apparatus can guide an MR-visible, sterile needle sleeve, which can have a hollow tube filled with contrast media, through the anus onto the inner wall of the colon. Due to the visibility of the contrast media in the sleeve, the apparatus can be guided to the exact position. The sleeve can incorporate a tube within the contrast media filled sleeve to insert the biopsy needle and to push this needle forward into the prostate. The apparatus can utilize various mechanical mechanisms to stereotactically move the needle or needle sleeve in various directions.

An embodiment in accordance with the present invention provides a device and method for a transrectal ultrasound (TRUS) guided prostate biopsy. The device includes an ultrasound wand equipped with a lateral fire ultrasound sensor. The ultrasound wand also defines a channel having an oblique path though the wand. The channel accommodates a biopsy needle, which can be pivoted as well inserted through the channel to different depths in order to perform a biopsy of the prostate. The device therefore uses only three degrees-of-freedom of movement in order to obtain the biopsy samples. Additionally, the ultrasound wand can be used to generate a three-dimensional image of the prostate.

The invention discloses a novel automatic prostate biopsy robot with remote center movement, mainly relating to the field of prostate biopsy, which solves the problems of large trauma and easy infection during prostate biopsy. The positioning module is installed on a robot fixing module. The imaging module is installed on the positioning module. The posture adjustment module is fixed on the positioning module. The depth control module is fixed on the attitude adjustment module; the wire rope transmission module is installed on the posture adjustment module. The posture adjusting module comprises a horizontal arc-shaped slide rail module and a vertical arc-shaped slide rail module. The unique virtual fixed point is determined in space through the random reciprocating motion of the arc-shaped slide block on the arc-shaped guide rail, and a puncturing point is determined in the left and right of the perineum through the positioning of the positioning module. Each movement of the inventionis carried out independently, and is automatically positioned by a control system. The movement of each module is free from interference, and the operation is convenient and the positioning is accurate.

The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and / or chemoprevention.

The invention provides a prostate biopsy puncture robot based on biplane ultrasonic image guidance. The prostate biopsy puncture robot comprises an angle control mechanism, a fixing mechanism, a vertical position adjusting mechanism and a puncture executing mechanism, wherein the angle control mechanism is used for adjusting the angles of an ultrasonic probe and a puncture overall mechanism; the fixing mechanism is supported on the angle control mechanism through a shafting and a relevant connecting piece and is used for clamping the ultrasonic probe; the vertical position adjusting mechanism is used for adjusting the distance between a puncture needle and the ultrasonic probe; the puncture executing mechanism is used for pushing the puncture needle; the vertical position adjusting mechanism is arranged on the shafting of the angle control mechanism through the connecting piece; and the puncture executing mechanism is fixedly arranged on a sliding table of the vertical position adjusting mechanism. According to the prostate biopsy puncture robot, ultrasonic images in two different planes of the prostate part of a patient are acquired through the transrectal ultrasonic probe, and the puncture needle is accurately controlled by moving the angle control mechanism, the vertical position adjusting mechanism and the puncture executing mechanism.

Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.

The invention relates to methods and kits for the diagnosis of prostate cancer (PCa) in a subject, for assessing or monitoring the response to a therapy in a subject having PCa or for monitoring the progression of prostate cancer PCa based on the detection of alteration in the expression levels of at least one gene selected from the group of PC A3, PSMA and PSGR. The invention relates as well to methods for assessing whether a subject has to be subjected to a prostate biopsy, said subject having a serum PSA range within 4-10 ng / mL.

The invention discloses a prostate biopsy robot, comprising a rotating driving device, a detector linear driving device, a detector rotating mechanism, a detector, a biopsy needle driving device, a biopsy needle and a control system. The rotating driving device comprises a chassis, a first servo motor, a main shaft and a disk, wherein the first servo motor drives the disk to rotate through the main shaft. A linear drive device of the detector is arranged on the disc and comprises a longitudinal guide rail lead screw mechanism and a transverse guide rod lead screw mechanism, wherein the transverse guide rod lead screw mechanism is arranged above the longitudinal guide rail lead screw mechanism. The detector rotating mechanism is arranged on the transverse guide rod lead screw mechanism. Andthe detector is mounted on the detector rotating mechanism. The driving device of the biopsy needle is fixedly connected with the disc, and comprises a vertical guide rail lead screw mechanism and aneedle feeding mechanism, wherein the needle feeding mechanism is connected with the vertical guide rail lead screw mechanism. The biopsy needle is arranged on the needle feeding mechanism. The invention has the advantages of compact structure, high automation degree, high matching degree of the detector and the biopsy needle, and can improve the biopsy precision, improve the operation quality andreduce the risk.

The invention relates to methods and kits for the diagnosis of prostate cancer (PCa) in a subject, for assessing or monitoring the response to a therapy in a subject having PCa or for monitoring the progression of prostate cancer PCa based on the detection of alteration in the expression levels of at least one gene selected from the group of PC A3, PSMA and PSGR. The invention relates as well to methods for assessing whether a subject has to be subjected to a prostate biopsy, said subject having a serum PSA range within 4-10 ng / mL.

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; b) calculating a genetic risk score (GRS) for the subject based on the genotype determined in step (a); and c) analyzing the GRS of the subject in combination with a prostate specific antigen (PSA) level of the subject to identify a prostate cancer detection rate for the subject, whereby a prostate cancer detection rate of greater than or equal to a reference value identifies the subject as a subject for whom a prostate biopsy is indicated.

The invention relates to a universal prostate biopsy device. The universal prostate biopsy device comprises a 3-axis movement module and a biopsy module, wherein the biopsy module is arranged on the 3-axis movement module; the 3-axis movement module comprises an x-direction movement mechanism, a y-direction movement mechanism and a z-direction movement mechanism; the biopsy module realizes the movement of the 3-axis movement module in the x direction, the y direction and the z direction; the biopsy module comprises a fixing plate, a rotating mechanism, an installing seat, an ultrasonic probe locking device and a biopsy needle assembly; the rotating mechanism and the installing seat are arranged on the fixing plate; the installing seat can realize the angle regulation through the rotating mechanism; the biopsy needle assembly realizes fine regulation through a fifth motor and a sixth motor; the universal prostate biopsy device also comprises a controller and a control handle; and the control handle controls the 3-axis movement module, a fourth motor, a fifth linear motor and a sixth linear motor through a controller. The universal prostate biopsy device has the advantages that through the control handle, the movement of the biopsy module in a multi-axis plane is realized; the operation is more flexible and convenient; and the equipment cost and the influence caused by artificialfactors are reduced.

A method of analyzing a plurality of biopsy cores extracted from a plurality of respective biopsy locations in a prostate is disclosed. The method comprises: measuring a level of a chemical element in each of the biopsy cores, and generating a chemical element map of at least a portion of the prostate based on the levels and the respective biopsy locations. In some embodiments, the method determines at least one additional biopsy location for a future biopsy in the prostate.

An embodiment of the invention relates to an adjustable puncture template. The adjustable puncture template comprises a rotary template assembly and a template frame body, wherein a through hole penetrating through a front surface and a rear surface of the template frame body is formed in the template frame body; the rotary template assembly is arranged in the through hole and can rotate based ona central shaft of the rotary template assembly, and a guide hole for a puncture needle to pass through is formed in the rotary template assembly; and an axial direction of the rotary template assembly is parallel to an axial direction of the through hole. The adjustable puncture template can flexibly adjust a puncture position, adapt to puncture requirements of different angles, expand puncture range, and improve efficiency and puncture precision of minimally invasive therapies such as puncture ablation and particle implantation. The puncture template is particularly suitable for prostate biopsy or puncture therapy and tissue biopsy of other parts.

An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, a mid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.

The invention discloses a detection method in the technical field of biological engineering, and specifically provides an early stage prostate cancer semi-quantitative diagnosis method utilizing double indication line immunity chromatography. Prostate cancer is a frequently-occurring disease among middle-aged and old males. According to statistics, prostate cancer has the highest incidence of disease in male cancer patients, and is the third cause of death following lung cancer and colorectal cancer. Currently, a PSA detection method used clinically is an ELISA and a CLIA method, etc. the above methods are time-consuming, energy-consuming and is not conducive to popularization and is expensive. An immunization colloidal gold technology has developed rapidly and has been applied widely to detections of infectious disease, early pregnancy and cancer, etc. The invention employs a colloidal gold immunity chromatography to establish a PSA rapid detection method which can realize a semi-quantitative determination of 4ng / mL-10ng / mL PSA ambiguous region and guide a prostate biopsy according to age.

A device for MR-guided endorectal prostate biopsy has a biopsy guidance device connected to an MR system that is secured to the patient support table, and is alignable via the MR system for alignment and guidance of the biopsy needle into a preselectable target area. The biopsy guidance device contains MR-imaging markers and is provided with a trajectory setting mechanism at which the previously selected and calculated trajectory can be set.

The invention presents tools to improve a 3-D image aided biopsy or treatment procedure for prostate gland by providing additional functionality and additional visual cues on an output image of the prostate, which may be generated substantially in real-time. The tools include i) the identification of various parts of prostate to classify as per regular classification in pathological reports, ii) Computing and displaying the insertion depth of needle with respect to a selected target point during the procedure, iii) Computing and displaying the distance from needle tip to prostate surface following a procedure and, iv) Calibration for misalignment of a 2-D imaging transducer when used under tracked motion for a procedure.

The invention discloses an adjusting device of an intra-cavity ultrasonic probe protection device and an application thereof. The adjusting device is used for prostate biopsy or radioactive particle implanting and comprises a tightening component, a fixing component, a guiding component and a connecting component. The tightening component is arranged on the fixing component, and a fixing portion is arranged on the fixing component and used for installing and fixing an ultrasonic probe protection sleeve. One end of the guiding component is movably connected with the fixing component, and the other end of the guiding component is fixedly connected with the connecting component. The connecting component is arranged below the fixing component and fixedly connected with the guiding component. Under the action of the tightening component, the fixing component can move along the guiding component; when the fixing component gets close to the connecting component, the ultrasonic probe protection device moves downwards and is close to the surface of an ultrasonic probe so that the ultrasonic probe protection device and the ultrasonic probe can be kept attached well; air in the space, between the inner wall of the upper portion of the ultrasonic probe protection sleeve and the external surface of the upper portion of the ultrasonic probe, for filling of medicinal ultrasonic coupling agents, is discharged, imaging quality is improved, and the usage quantity of the coupling agents is reduced.

The present disclosure relates to methods for the early detection of ERG over-expression, gene rearrangements, and diagnosis and / or prognosis of prostate cancer using a combined ERG IHC-FISH assay.

A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.

The invention discloses a biplane prostate biopsy and seed implantation system. The biplane prostate biopsy and seed implantation system comprises a probe, a puncture needle, a fixing device, a moving device, a positioning device and a rotating device. The probe is connected to the fixing device. The fixing device is connected to the moving device. The rotating device is connected to the moving device. The positioning device is disposed on the rotating device and connected with the puncture needle. The puncture needle is parallel to the probe, and a needle head of the puncture needle and a head of the probe orient towards the same direction. The moving device is used for driving the fixing device to drive the probe and driving the rotating device to drive the puncture needle to move simultaneously. A rotation driving part is used for driving the positioning device to drive the puncture needle to rotate along the radial surface of the puncture needle. The positioning device is used for driving the puncture needle to move on the radial surface and axial surface of the puncture needle. The biplane prostate biopsy and seed implantation system is high in precision and easy to operate.