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Methods and kits for the diagnosis of prostate cancer

A technology for prostate cancer and prostate, applied in the field of diagnosis and diagnosis of prostate cancer, can solve problems such as decreased specificity

Inactive Publication Date: 2013-07-24
FUNDACIO INST DE RECERCA HOSPITAL UNIVERSITARI VALL DHEBRON FUNDACIO PRIVADA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the specificity of a single marker with a sensitivity > 95% will be greatly reduced

Method used

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  • Methods and kits for the diagnosis of prostate cancer
  • Methods and kits for the diagnosis of prostate cancer
  • Methods and kits for the diagnosis of prostate cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0216] Identification of a trigene group for early detection of PCa in urine

[0217] 1. Materials and Methods

[0218] 1.1 Patient and urine collection

[0219] This study was approved by the Institutional Review Board of the Vall d'Hebron Hospital. All urine samples were obtained from the Urology Department of Vall d'Hebron Hospital (Barcelona-Spain) and collected immediately after prostate massage (PM) from 198 men who underwent prostate biopsy indicated as abnormal digital rectal examination (DRE) and / or Serum PSA above 4.0 ng / ml. Obtain written informed consent from all patients. Patients with other known tumors and / or who had previously received PCa therapy were excluded from this study. Table 1 shows the clinical and pathological information data of these 154 patients.

[0220] PM method of operation: PM is performed by systematically applying digital weight pressure to the prostate from the bottom to the top, each lobe from the side to the midline.

[0221] ...

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Abstract

The invention relates to methods and kits for the diagnosis of prostate cancer (PCa) in a subject, for assessing or monitoring the response to a therapy in a subject having PCa or for monitoring the progression of prostate cancer PCa based on the detection of alteration in the expression levels of at least one gene selected from the group of PC A3, PSMA and PSGR. The invention relates as well to methods for assessing whether a subject has to be subjected to a prostate biopsy, said subject having a serum PSA range within 4-10 ng / mL.

Description

technical field [0001] The present invention is in the field of diagnostics, and more particularly, in the field of diagnosing prostate cancer by means of combinations of genes whose expression in prostate cancer cells is lower than their expression in normal (i.e. non-cancerous) prostate cells overexpressed. technical background [0002] Prostate cancer (PCa) has transformed into the most prevalent cancer among Western men, killing more men than any other cancer (except lung cancer). Men have an estimated lifetime risk of 1 in 6 developing these cancers and a 1 in 36 risk of dying from metastatic PCa during their lifetime. Although the introduction of the prostate-specific antigen (PSA) test in the late 1980s led to a substantial increase in the detection of PCa, the mortality rate did not decrease significantly (Jemal, A., et al., (2007). Cancer statistics, 2007. CA: a cancer journal for clinicians, 2009, June9, 57, 43-66). There are two main reasons for this: the widel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/16C12Q2600/118C12Q2600/158
Inventor 安德列亚斯·多利玛丽娜·里加图雷西纳胡安·莫罗特罗布莱斯米格尔·阿巴尔波萨达豪梅·雷文托斯普伊赫哈内尔
Owner FUNDACIO INST DE RECERCA HOSPITAL UNIVERSITARI VALL DHEBRON FUNDACIO PRIVADA
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