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Composition comprising vicenin-2 having a beneficial effect on neurological and/or cognitive function

a technology of vicenin-2 and neuronal function, which is applied in the field of food, dietary supplement and drug composition, can solve the problems of symptomatic benefits, reducing the efficiency of neuronal communication, and massive economic burden of alzheimer's diseas

Inactive Publication Date: 2014-10-30
AMINO CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Vicenin 2 and its derivatives demonstrate multiple therapeutic benefits, including improved cognitive functions, neuroleptic, anti-depressive effects, and anti-inflammatory properties, offering a higher success rate in treating neurodegenerative disorders like Alzheimer's by maintaining and improving neurological and brain health.

Problems solved by technology

There is no cure for the disease, which worsens as it progresses, and eventually leads to death.
The economic burden of Alzheimer's disease is massive and currently approved drugs do not prevent or reverse the disease and provide only modest symptomatic benefits.
A combination of several causes may lead to the development of plaques in the brain, which decrease the efficiency of neuronal communication leading to death of neurons.
Not many drugs are approved for the treatment of dementia such as Alzheimer.
[1,1] Despite considerable efforts by academic researchers and pharmaceutical and food industry, the development of novel ingredients for the maintenance and improvement of neurological and brain function and to prevent the development and to slow down the progression of dementia and Alzheimer disease has been dragging and did not lead to many innovations.

Method used

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  • Composition comprising vicenin-2 having a beneficial effect on neurological and/or cognitive function
  • Composition comprising vicenin-2 having a beneficial effect on neurological and/or cognitive function
  • Composition comprising vicenin-2 having a beneficial effect on neurological and/or cognitive function

Examples

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example 1

Vicenin 2 and Perilla Extract Comprising Vicenin 2 and their Neurological Efficacy

Methods and Compounds

[0102]Purpose of this example was the evaluation of the acute neuroactive effects of vicenin 2 (named AUC-V) and of Perilla extract (named AUC-P) comprising and standardized on Vicenin 2 on the neuronal activity of murine frontal cortex networks in vitro by means of electrophysiological multi-channel recordings. In this system, cells or tissues are grown directly on the chip surface and communicate via chemical and electrical signals. The MEA-neurochip allows the non-invasive, long-term, multisite recording of electrical signal patterns of primary neuronal networks. Said MEA-neurochip technology enables the characterization of network activity pattern on the single-cell action-potential level and on the level of complex neuronal networks as the basic functional units. This can also be used as a test system for investigating neuro-physiological properties of compounds. Despite the c...

example 2

Perilla Extract Comprising and Standardized on Vicenin 2 has the Ability to Reduce TNFα

[0130]This study investigated the efficacy of Perilla extract comprising vicenin 2 to contribute to reduce TNFα levels. The study was designed as an ex vivo study, where human whole blood samples were treated with LPS, a bacterial blend, to stimulate inflammation which leads to an increase of the cytokine TNFα. Furthermore, the effect to reduce TNFα by Perilla extract was measured in comparison to a negative and positive control. Perilla extract demonstrated a dose-depending effect to reduce TNFα (see FIG. 3).

[0131]Surprisingly, the extract as well as the isolated vicenin 2 demonstrated anti-inflammatory effects. Perilla extract demonstrated TNFα inhibiting efficacy within this ex vivo study showing a further beneficial effect in treatment if a cognitive disorder. In addition, TNFα has been recognized to be a gliatransmitter that regulates synaptic function in neural networks. Anti-TNF α treatment...

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Abstract

The invention relates to an active ingredient and / or to a composition having beneficial effect on neurological and cognitive functions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a U.S. National Stage application of PCT / EP2012 / 074010 filed 29 Nov. 2012, which claims priority to European Patent Application 11009430.7 filed 29 Nov. 2011, European Patent Application 12163578.3 filed 10 Apr. 2012, U.S. Provisional Patent Application 61 / 564,374 filed 29 Nov. 2011, and U.S. Provisional Patent Application 61 / 622,260 filed 10 Apr. 2012, the entire disclosures of which are hereby incorporated by reference.TECHNICAL FIELD[0002]The invention relates to a food, a dietary supplement and a drug composition comprising as an active ingredient vicenin 2 or a biologically active analogue thereof, and especially its beneficial effects to maintain and / or improve neurological and brain function and to prevent, delay onset, control and / or treat a cognitive dysfunction, condition, disorder or disease, e.g. dementia such as Alzheimer disease.BACKGROUND OF THE INVENTION[0003]Maintenance or improvement of neurological a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7048A61K45/06A61K36/535
CPCA61K31/7048A61K45/06A61K36/535A61K36/00A61P25/16A61P25/28A61P25/14A61P25/20A61P25/22A61P25/24A61K2300/00A23L33/105A23V2002/00A61K2236/331A23L33/125A61P25/00A23V2200/322
Inventor BUCHWALD-WERNER, SYBILLEFUJII, HAJIME
Owner AMINO CHEM
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