Magnesium-containing products and uses thereof

Abstract

A composition including a hydrate form of magnesium oxide, denoted as MgO.(H2O)n, at a concentration ranging from 1 to 100 weight percent (wt %), where n is any value from 0.1 to 2. The composition may further include MgO at a concentration ranging from 0 to 99 wt %; or Mg(OH)2, at a concentration ranging from 0 to 99 wt %; or Mg(OH)2 at a concentration ranging from 0 to 99 wt %, and MgO, at a concentration ranging from 0 to 99 wt %.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of US Provisional Patent Application No. US 61 / 826,736 filed on 23 May 2013. The disclosure of this prior application is considered part of and is incorporated by reference in the disclosure of this application.FIELD AND BACKGROUND OF THE INVENTION[0002]The present invention relates to the field of supplemental products, and more particularly, but not exclusively, to novel magnesium (Mg)-containing products, method of preparing same and uses thereof as magnesium supplements with enhanced bioavailability in humans.[0003]Magnesium is a natural element widely diffused in living organisms, especially in mammals, wherein the largest concentration thereof occurs in bones. The participation of magnesium ions in the human body has been established in most reactions of carbohydrates, lipids, nucleic acids, and in protein metabolism.[0004]Magnesium is the fourth most abundant cation in the human body and plays an essential physiolo...

AI Technical Summary

Benefits of technology

The present invention is about creating new magnesium products that can be used as supplements to improve the body's absorption of magnesium. The invention includes a special form of magnesium oxide that is mixed with water to create a composition. This special form of magnesium oxide helps to prevent the magnesium from clumping together and ensures that the magnesium is readily available for the body to use.

Problems solved by technology

However, it has been shown that there is no apparent correlation between serum and tissue magnesium levels, with exception of bone and interstitial fluid, and therefore serum magnesium measurements do not accurately reflect the amount of magnesium present in the body.

However, as the magnesium food content in the Western world is consistently reducing, magnesium deficiency, or hypomagnesaemia, has become a prevalent condition.

Surveys show that a substantial number of adults in the United States fail to consume recommended daily amounts of magnesium.

Magnesium deficiency can occur in babies from birth, when the mother was already depleted of her own magnesium reserves, or when the baby is poorly supplied with magnesium, and / or undergoes high magnesium losses from his or her organism.

However, the decreased absorption associated with oral administration poses a significant obstacle in administration (The Merck Manual Home Health Handbook, 2009, Chapter 10).

Non-absorbed magnesium (not uptaken by cells), due to high oral loads or inefficient absorption, can cause a number of side effects, including diarrhea, heartburn, nausea, and upset stomach.

It is to be noted that oral administration of acidic magnesium salts, which generate relatively strong acids in the stomach (e.g., magnesium chloride and magnesium sulfate) is limited by the tolerable amount that can be taken, since it can cause non-tolerable acidity in the stomach.

Since magnesium has no specific target tissue, its bioavailability cannot be assessed directly.

However, conflicting data regarding the absorption rates of magnesium as a function of the supplement formulation are found in the art.

Efforts were made to utilize small MgO particles, yet, are hindered by the tendency of the magnesium oxide particles to strongly agglomerate.

Resulting agglomerates require a high shear force for re-pulverization at the time of incorporation into absorbable preparations, and thus adversely affect other ingredients in any planned preparations.

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