Compositions and methods for the treatment of inflammatory bowel disease

a technology for inflammatory bowel disease and compositions, applied in the field of compound and compositions for the treatment of inflammatory bowel disease, can solve the problems of mucus in the stool, nutrient deficiencies, weight loss, etc., and achieve the effect of treating, preventing and/or ameliorating the effects of the condition

Active Publication Date: 2016-05-05
CELLIXBIO PTE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present invention provides compounds, compositions containing these compounds and methods for using

Problems solved by technology

As the disease progresses from mild to more severe, the patient may also experience weight loss, fatigue, loss of

Method used

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  • Compositions and methods for the treatment of inflammatory bowel disease
  • Compositions and methods for the treatment of inflammatory bowel disease
  • Compositions and methods for the treatment of inflammatory bowel disease

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Definitions

[0036]As used herein, the following terms and phrases shall have the meanings set forth below. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art.

[0037]The compounds of the present invention can be present in the form of pharmaceutically acceptable salts. The compounds of the present invention can also be present in the form of pharmaceutically acceptable esters (i.e., the methyl and ethyl esters of the acids of formula I and formula II to be used as prodrugs). The compounds of the present invention can also be solvated, i.e. hydrated. The solvation can be affected in the course of the manufacturing process or can take place i.e. as a consequence of hygroscopic properties of an initially anhydrous compound of formula I and formula II (hydration).

[0038]Compounds that have the same molecular formula but differ in the nature or sequence of bonding of their atoms or the arra...

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PUM

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Abstract

The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria.

Description

PRIORITY[0001]This application is a Continuation application of and claims priority to the U.S. non-provisional application Ser. No. 14 / 533,111 filed on Nov. 5, 2014. The U.S. non-provisional application Ser. No. 14 / 533,111 further claims the priority of the Patent Cooperation Treaty (PCT) application # PCT / IB2013 / 053982 titled “COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE” filed on May 15, 2013 Published with WIPO Publication # WO / 2013 / 175357, which further claims priority to parent application 2062 / CHE / 2012 filed on May 23, 2012 in the country of India. The entire disclosure of the priority applications are relied on for all purposes and is incorporated into this application by reference.FIELD OF THE INVENTION[0002]This disclosure generally relates to compounds and compositions for the treatment of Inflammatory Bowel Disease. More particularly, this invention relates to treating subjects with a pharmaceutically acceptable dose of compounds, stereoisomer...

Claims

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Application Information

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IPC IPC(8): A61K31/245C07C243/22A61K31/655C07C235/74
CPCA61K31/245A61K31/655C07C243/22C07C235/74A61K31/202A61K31/235A61K31/606A61K45/06C07C233/54C07C233/55C07C251/86C07C2601/16A61K2300/00
Inventor KANDULA, MAHESH
Owner CELLIXBIO PTE LTD
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