Compositions and methods for the treatment of inflammatory bowel disease

Abstract

The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria.

Description

PRIORITY[0001]This application is a Continuation application of and claims priority to the U.S. non-provisional application Ser. No. 14 / 533,111 filed on Nov. 5, 2014. The U.S. non-provisional application Ser. No. 14 / 533,111 further claims the priority of the Patent Cooperation Treaty (PCT) application # PCT / IB2013 / 053982 titled “COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE” filed on May 15, 2013 Published with WIPO Publication # WO / 2013 / 175357, which further claims priority to parent application 2062 / CHE / 2012 filed on May 23, 2012 in the country of India. The entire disclosure of the priority applications are relied on for all purposes and is incorporated into this application by reference.FIELD OF THE INVENTION[0002]This disclosure generally relates to compounds and compositions for the treatment of Inflammatory Bowel Disease. More particularly, this invention relates to treating subjects with a pharmaceutically acceptable dose of compounds, stereoisomer...

AI Technical Summary

Benefits of technology

The present invention provides compounds, compositions, and methods for treating inflammatory bowel disease and its associated complications. The compounds and compositions are made up of specific formulas I and II, which are described in detail below. The methods of treatment involve administering the compounds or compositions to patients in need of treatment. The compounds and compositions have various uses, including treating metabolic conditions, cancers, and other complications associated with inflammatory bowel disease. The patent text also includes a kit for use in treating inflammatory bowel disease.

Problems solved by technology

As the disease progresses from mild to more severe, the patient may also experience weight loss, fatigue, loss of appetite that may result in nutrient deficiencies, mucus in the stool, severe rectal bleeding, fever, and anemia.

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