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Methods for identifying patients at risk for costimulation blockade resistant rejection

a technology of costimulation blockade and patient risk, applied in the direction of instruments, biological material analysis, measurement devices, etc., can solve the problems of no predictive assay to identify patients at risk of costimulation blockade resistant rejection, and the recipient is at greater risk of complications and graft loss

Inactive Publication Date: 2016-06-02
BRISTOL MYERS SQUIBB CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for predicting if a person is at risk of rejection after a transplant by measuring the percentage of certain T cells in their blood. This method can help doctors make better decisions about which patients need to be treated with costimulation blockade therapy to prevent rejection. Overall, this invention can help improve the accuracy of transplant predictions and increase the success of transplant procedures.

Problems solved by technology

Further, while the introduction of kidneys from extended criteria donors has been necessary to alleviate donor organ shortages, recipients are at greater risk of complications and graft loss than recipients of living or standard criteria deceased donor kidneys (Tullius, S. G. et al., Eur.
At present, there are no predictive assays to identify patients at risk of costimulation blockade resistant rejection.

Method used

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  • Methods for identifying patients at risk for costimulation blockade resistant rejection
  • Methods for identifying patients at risk for costimulation blockade resistant rejection
  • Methods for identifying patients at risk for costimulation blockade resistant rejection

Examples

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example 1

[0054]Early costimulation blockade resistant rejection has been seen in some patients on belatacept-based immunosuppression. Hypothesizing that T cell phenotype might prospectively identify patients at risk for costimulation blockade resistant rejection, patients receiving belatacept-based costimulation blockade, were studied by specifically quantifying terminally differentiated memory cells expressing CD57, a marker of T cell senescence, and relating this expression to clinical outcome.

[0055]Methods: Samples from renal allograft recipients receiving belatacept-based immunosuppression were selected from an IRB-approved tissue acquisition protocol.

Study Population:

[0056]Organ transplant recipients, candidates for organ transplantation, and their organ donors under evaluation at the Emory University Hospital / Emory Transplant Center (Emory) or Children's Healthcare of Atlanta (CHOA) were considered for study.

Inclusion Criteria:

[0057]Recipients of or candidates for organ transplantation...

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Abstract

The present invention provides methods utilizing changes in CD4+CD57+ T cells levels for determining the susceptibility of a transplant patient or patient in need thereof to costimulation blockade resistant rejection. These methods are useful for identifying effective drug regimens for the treatment of immune disorders associated with graft transplantation and / or maintenance of a transplant.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application Ser. No. 61 / 806,206, filed Mar. 28, 2013; the entire content of which is incorporated herein by reference.[0002]Throughout this application various publications are referenced. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.FIELD OF THE INVENTION[0003]This invention relates to methods for determining the susceptibility of a transplant patient to costimulation blockade resistant rejection. These methods are useful for identifying effective drug regimens for the treatment of immune disorders associated with graft transplantation and / or maintenance of a transplant.BACKGROUND OF THE INVENTION[0004]Given the central role of T-cells in transplant rejection, a common goal among current immunosuppressive therapies is to block T-c...

Claims

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Application Information

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IPC IPC(8): G01N33/569
CPCG01N33/56972G01N2800/52G01N2800/245
Inventor KIRK, ALLAN DRAE, JACLYNTOWNSEND, ROBERT M.
Owner BRISTOL MYERS SQUIBB CO
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