Combination of cross-linked hyaluronic acids and method of preparing the same

a technology of cross-linked hyaluronic acid and cross-linked comb, which is applied in the field of preparation of cross-linked hyaluronic acid and a combination, can solve the problems that hyaluronic acid of animal origin such as rooster combs may have a quality control problem, and achieve the effect of low viscoelasticity and effective use in osteoarthritis treatmen
US20180215840A1Inactive Publication Date: 2018-08-02HANMI PHARMA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
HANMI PHARMA
Publication Date
2018-08-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided are a method of preparing a cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa, including cross-linking hyaluronic acid with an epoxy-based cross-linking agent having at least two epoxy functional groups in an ethanol-containing aqueous alkaline; a method of preparing a cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa, including cross-linking the same cross-linked hyaluronic acid with the same epoxy-based cross-linking agent in an aqueous alkaline solution; and a combination of the cross-linked hyaluronic acids one having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa and the other having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application is a National Phase Application filed under 35 U.S.C. 371 as a national stage of PCT / KR2016 / 005819, filed Jun. 1, 2016, and claims the benefit of Korean Patent Application No. 10-2016-0011843, filed on Jan. 29, 2016, and Korean Patent Application No. 10-2016-0012519, filed on Feb. 1, 2016, in the Korean Intellectual Property Office, the disclosures of which are incorporated herein in their entireties by reference.TECHNICAL FIELD

[0002] The present disclosure relates to a preparation method of a cross-linked hyaluronic acid and a combination of cross-linked hyaluronic acids having a viscoelasticity appropriate for use in the living body, comprising the cross-linked hyaluronic acid prepared using the same method.BACKGROUND ART

[0003] Hyaluronic acids are a biopolymer material including linearly linked repeating units consisting of N-acetyl-D-glucosamine and D-glucuronic acid, and are also known to be prevalent in animal placenta...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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