Formulation having controlled, delayed release of active ingredient

a technology of active ingredients and formulations, applied in the direction of heterocyclic compound active ingredients, drug compositions, cardiovascular disorders, etc., can solve the problems of short elimination half-life of 2-6 hours, and limited bioavailability of about 25-30%, so as to avoid undesired dose dumping of active ingredients
US20200246270A1Inactive Publication Date: 2020-08-06MERCK PATENT GMBH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MERCK PATENT GMBH
Publication Date
2020-08-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to novel pharmaceutical formulations which have controlled, delayed release of active ingredient, and to a process for the preparation of such formulations. The invention additionally relates to the use of these novel pharmaceutical administration forms as medicaments for the treatment of diseases which require delayed release of the active ingredient, such as hypertension, or asthmatic diseases.
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Description

[0001] The present invention relates to novel pharmaceutical formulations which have controlled, delayed release of active ingredient, and to a process for the preparation of such formulations. The invention additionally relates to the use of these novel pharmaceutical administration forms as medicaments for the treatment of diseases which require delayed release of the active ingredient, such as hypertension, or asthmatic diseases.PRIOR ART

[0002] Propranolol belongs to the active ingredient group of beta blockers having antihypertensive, anti-anginal and anti-arrhythmic properties. Although this active ingredient was introduced into therapy as the first β-receptor blocker as long ago as 1964, and in the meantime a multiplicity of different derivatives in diverse medicament forms are known, especially in order to avoid undesired effects and in order to achieve certain differences in action, propranolol continues to be a frequently administered beta blocker.

[0003] The substance exhibits...

Claims

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